Revisiting cerebral thromboangiitis obliterans

Carrie Hurelbrink, Yael Barnett, Michael Buckland, Mark Wilkinson, Jonathan Leicester, Craig Anderson, Jeffrey Brennan, Michael Barnett

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    We describe a 56-year-old patient with progressive cognitive decline in the context of heavy tobacco use and migraine, and imaging evidence of an occlusive terminal cerebral vasculopathy. The results of brain biopsy recapitulated the pathological features described by Lindenberg and Spatz in their classic 1939 treatise on cerebral thromboangiitis obliterans, or cerebral Buerger's disease. Although the condition is associated with heavy smoking, the identification of a hypercoagulable state in our patient suggests a multifactorial pathogenesis. The diagnosis of cerebral thromboangiitis obliterans in life is facilitated by modern neuroimaging and should prompt immediate cessation of smoking and a search for an underlying prothrombotic tendency.

    Original languageEnglish
    Pages (from-to)141-145
    Number of pages5
    JournalJournal of the Neurological Sciences
    Issue number1-2
    Publication statusPublished - 15 Jun 2012


    • Buerger's disease
    • Cerebral thromboangiitis obliterans
    • Cerebrovascular disease
    • Spatz-Lindenberg
    • Thrombosis
    • Vascular dementia


    Dive into the research topics of 'Revisiting cerebral thromboangiitis obliterans'. Together they form a unique fingerprint.

    Cite this