TY - JOUR
T1 - Ribosome inactivating proteins: current status and biomedical applications.
AU - Puri, Munish
AU - Kaur, Inderdeep
AU - Perugini, Matthew
AU - Gupta, Raghbir
PY - 2012/7
Y1 - 2012/7
N2 - Ribosome-inactivating proteins (RIPs) are mainly present in plants and function to inhibit protein synthesis through the removal of adenine residues from eukaryotic ribosomal RNA (rRNA). They are broadly classified into two groups: type I and type II. Type I RIPs are a diverse family of proteins comprising a single polypeptide chain, whereas type II RIPs are heterodimeric glycoproteins comprising an A-chain (functionally equivalent to a type I RIP) linked via a disulphide bond to a B chain, mediating cell entry. In this review, we describe common type I and type II RIPs, their diverse biological functions, mechanism of cell entry, stability in plasma and antigenicity. We end with a discussion of promising applications for RIPs in biomedicine.
AB - Ribosome-inactivating proteins (RIPs) are mainly present in plants and function to inhibit protein synthesis through the removal of adenine residues from eukaryotic ribosomal RNA (rRNA). They are broadly classified into two groups: type I and type II. Type I RIPs are a diverse family of proteins comprising a single polypeptide chain, whereas type II RIPs are heterodimeric glycoproteins comprising an A-chain (functionally equivalent to a type I RIP) linked via a disulphide bond to a B chain, mediating cell entry. In this review, we describe common type I and type II RIPs, their diverse biological functions, mechanism of cell entry, stability in plasma and antigenicity. We end with a discussion of promising applications for RIPs in biomedicine.
UR - http://www.scopus.com/inward/record.url?scp=84863519513&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2012.03.007
DO - 10.1016/j.drudis.2012.03.007
M3 - Review article
VL - 17
SP - 774
EP - 783
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 13-14
ER -