Risk factors for stroke, myocardial infarction, or death following carotid endarterectomy: Results from the International Carotid Stenting Study.

D Doig, E Turner, J Dobson, R Featherstone, G de Borst, G Stansby, J Beard, S Engelter, T Richards, Martin Brown, International carotid stenting study investigators, David Schultz, P. Rogers

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Abstract

Objectives Carotid endarterectomy (CEA) is standard treatment for symptomatic carotid artery stenosis but carries a risk of stroke, myocardial infarction (MI), or death. This study investigated risk factors for these procedural complications occurring within 30 days of endarterectomy in the International Carotid Stenting Study (ICSS). Methods Patients with recently symptomatic carotid stenosis >50% were randomly allocated to endarterectomy or stenting. Analysis is reported of patients in ICSS assigned to endarterectomy and limited to those in whom CEA was initiated. The occurrence of stroke, MI, or death within 30 days of the procedure was reported by investigators and adjudicated. Demographic and technical risk factors for these complications were analysed sequentially in a binomial regression analysis and subsequently in a multivariable model. Results Eight-hundred and twenty-one patients were included in the analysis. The risk of stroke, MI, or death within 30 days of CEA was 4.0%. The risk was higher in female patients (risk ratio [RR] 1.98, 95% CI 1.02-3.87, p = .05) and with increasing baseline diastolic blood pressure (dBP) (RR 1.30 per +10 mmHg, 95% CI 1.02-1.66, p = .04). Mean baseline dBP, obtained at the time of randomization in the trial, was 78 mmHg (SD 13 mmHg). In a multivariable model, only dBP remained a significant predictor. The risk was not related to the type of surgical reconstruction, anaesthetic technique, or perioperative medication regimen. Patients undergoing CEA stayed a median of 4 days before discharge, and 21.2% of events occurred on or after the day of discharge. Conclusions Increasing diastolic blood pressure was the only independent risk factor for stroke, MI, or death following CEA. Cautious attention to blood pressure control following symptoms attributable to carotid stenosis could reduce the risks associated with subsequent CEA.

Original languageEnglish
Pages (from-to)688-694
Number of pages7
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume50
Issue number6
DOIs
Publication statusPublished - Dec 2015
Externally publishedYes

Keywords

  • Carotid artery stenosis
  • Carotid atherosclerosis
  • Carotid endarterectomy

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    Doig, D., Turner, E., Dobson, J., Featherstone, R., de Borst, G., Stansby, G., Beard, J., Engelter, S., Richards, T., Brown, M., International carotid stenting study investigators, Schultz, D., & Rogers, P. (2015). Risk factors for stroke, myocardial infarction, or death following carotid endarterectomy: Results from the International Carotid Stenting Study. European Journal of Vascular and Endovascular Surgery, 50(6), 688-694. https://doi.org/10.1016/j.ejvs.2015.08.006