Risk of cancer in patients with biopsy-proven giant cell arteritis

Catherine Hill, Antonia Cole, M Rischmueller, T Dodd, Mark Coleman, Graham Tucker, Peter Roberts-Thomson

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    Abstract

    Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA. There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6). This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.

    Original languageEnglish
    Pages (from-to)756-759
    Number of pages4
    JournalRheumatology
    Volume49
    Issue number4
    DOIs
    Publication statusPublished - 2010

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    Hill, C., Cole, A., Rischmueller, M., Dodd, T., Coleman, M., Tucker, G., & Roberts-Thomson, P. (2010). Risk of cancer in patients with biopsy-proven giant cell arteritis. Rheumatology, 49(4), 756-759. https://doi.org/10.1093/rheumatology/kep409