Risk of cancer in patients with biopsy-proven giant cell arteritis

Catherine Hill; Antonia Cole; M Rischmueller; T Dodd; Mark Coleman; Graham Tucker; Peter Roberts-Thomson

doi:10.1093/rheumatology/kep409

Risk of cancer in patients with biopsy-proven giant cell arteritis

Catherine Hill, Antonia Cole, M Rischmueller, T Dodd, Mark Coleman, Graham Tucker, Peter Roberts-Thomson

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Abstract

Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA. There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6). This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.

Original language	English
Pages (from-to)	756-759
Number of pages	4
Journal	Rheumatology
Volume	49
Issue number	4
DOIs	https://doi.org/10.1093/rheumatology/kep409
Publication status	Published - Apr 2010

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title = "Risk of cancer in patients with biopsy-proven giant cell arteritis",

abstract = "Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA. There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6). This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.",

author = "Catherine Hill and Antonia Cole and M Rischmueller and T Dodd and Mark Coleman and Graham Tucker and Peter Roberts-Thomson",

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T1 - Risk of cancer in patients with biopsy-proven giant cell arteritis

AU - Hill, Catherine

AU - Cole, Antonia

AU - Rischmueller, M

AU - Dodd, T

AU - Coleman, Mark

AU - Tucker, Graham

AU - Roberts-Thomson, Peter

PY - 2010/4

Y1 - 2010/4

N2 - Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA. There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6). This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.

AB - Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA. There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6). This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.

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Risk of cancer in patients with biopsy-proven giant cell arteritis

Abstract

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