@article{d8e0bddf48ac476a9090218f0dc03b73,
title = "Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry",
abstract = "Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3–2.3) versus 2.3 (IQR 1.8–2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32–9.35) vs 4.34 (4.16–4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. Conclusion: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF.",
keywords = "Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF",
author = "Sawhney, {Jitendra PS.} and Kothiwale, {Veerappa A.} and Vikas Bisne and Rajashekhar Durgaprasad and Praveen Jadhav and Manoj Chopda and Velam Vanajakshamma and Ramdhan Meena and Govindan Vijayaraghavan and Kamaldeep Chawla and Jagan Allu and Pieper, {Karen S.} and {John Camm}, A. and Kakkar, {Ajay K.} and {GARFIELD-AF Investigators} and Bassand, {Jean Pierre} and Fitzmaurice, {David A.} and Goldhaber, {Samuel Z.} and Shinya Goto and Sylvia Haas and Werner Hacke and Mantovani, {Lorenzo G.} and Frank Misselwitz and Turpie, {Alexander G.G.} and {van Eickels}, Martin and Verheugt, {Freek W.A.} and Gloria Kayani and Fox, {Keith A.A.} and Gersh, {Bernard J.} and Luciardi, {Hector Lucas} and Harry Gibbs and Marianne Brodmann and Frank Cools and Barretto, {Antonio Carlos Pereira} and Connolly, {Stuart J.} and Alex Spyropoulos and John Eikelboom and Ramon Corbalan and Dayi Hu and Petr Jansky and Nielsen, {J{\o}rn Dalsgaard} and Hany Ragy and Pekka Raatikainen and {Le Heuzey}, {Jean Yves} and Harald Darius and Matyas Keltai and Sanjay Kakkar and Sawhney, {Jitendra Pal Singh} and Giancarlo Agnelli and Giuseppe Ambrosio and Y. Koretsune and {S{\'a}nchez D{\'i}az}, {Carlos Jerjes} and {Ten Cate}, Hugo and Dan Atar and Janina Stepinska and Elizaveta Panchenko and Lim, {Toon Wei} and Barry Jacobson and Seil Oh and Xavier Vi{\~n}olas and Marten Rosenqvist and Jan Steffel and Pantep Angchaisuksiri and Ali Oto and Alex Parkhomenko and {Al Mahmeed}, Wael and David Fitzmaurice and Hu, {D. Y.} and Chen, {K. N.} and Zhao, {Y. S.} and Zhang, {H. Q.} and Chen, {J. Z.} and Cao, {S. P.} and Wang, {D. W.} and Yang, {Y. J.} and Li, {W. H.} and Yin, {Y. H.} and Tao, {G. Z.} and P. Yang and Chen, {Y. M.} and He, {S. H.} and Ying Wang and Yong Wang and Fu, {G. S.} and X. Li and Wu, {T. G.} and Cheng, {X. S.} and Yan, {X. W.} and Zhao, {R. P.} and Chen, {M. S.} and Xiong, {L. G.} and P. Chen and Y. Jiao and Y. Guo and L. Xue and Wang, {F. Z.} and H. Li and Yang, {Z. M.} and Bai, {C. L.} and J. Chen and Chen, {J. Y.} and X. Chen and S. Feng and Fu, {Q. H.} and Gao, {X. J.} and Guo, {W. N.} and He, {R. H.} and He, {X. A.} and Hu, {X. S.} and Huang, {X. F.} and B. Li and J. Li and L. Li and Li, {Y. H.} and Liu, {T. T.} and Liu, {W. L.} and Liu, {Y. Y.} and Lu, {Z. C.} and Luo, {X. L.} and Ma, {T. Y.} and Peng, {J. Q.} and X. Sheng and Shi, {X. J.} and Sun, {Y. H.} and G. Tian and K. Wang and L. Wang and Wu, {R. N.} and Q. Xie and Xu, {R. Y.} and Yang, {J. S.} and Yang, {L. L.} and Q. Yang and Y. Ye and Yu, {H. Y.} and Yu, {J. H.} and T. Yu and H. Zhai and Q. Zhan and Zhang, {G. S.} and Q. Zhang and R. Zhang and Y. Zhang and Zheng, {W. Y.} and B. Zhou and Zhou, {Z. H.} and Zhu, {X. Y.} and S. Kakkar and Sawhney, {J. P.S.} and P. Jadhav and R. Durgaprasad and {Ravi Shankar}, {A. G.} and Rajput, {R. K.} and K. Bhargava and R. Sarma and A. Srinivas and D. Roy and Nagamalesh, {U. M.} and M. Chopda and R. Kishore and G. Kulkarni and P. Chandwani and Pothiwala, {R. A.} and {Padinhare Purayil}, M. and S. Shah and K. Chawla and Kothiwale, {V. A.} and B. Raghuraman and G. Vijayaraghavan and Vijan, {V. M.} and G. Bantwal and V. Bisne and A. Khan and Gupta, {J. B.} and S. Kumar and D. Jain and S. Abraham and D. Adak and A. Barai and H. Begum and P. Bhattacharjee and M. Dargude and D. Davies and B. Deshpande and P. Dhakrao and V. Dhyani and S. Duhan and M. Earath and A. Ganatra and S. Giradkar and V. Jain and R. Karthikeyan and L. Kasala and S. Kaur and S. Krishnappa and A. Lawande and B. Lokesh and N. Madarkar and R. Meena and P. More and D. Naik and K. Prashanth and M. Rao and Rao, {N. M.} and N. Sadhu and D. Shah and M. Sharma and P. Shiva and S. Singhal and S. Suresh and V. Vanajakshamma and Panse, {S. G.} and Y. Koretsune and S. Kanamori and K. Yamamoto and K. Kumagai and Y. Katsuda and K. Sadamatsu and F. Toyota and Y. Mizuno and I. Misumi and H. Noguchi and S. Ando and T. Suetsugu and M. Minamoto and Hiroshi Oda and K. Shiraishi and S. Adachi and K. Chiba and H. Norita and M. Tsuruta and T. Koyanagi and H. Ando and T. Higashi and K. Okada and S. Azakami and S. Komaki and K. Kumeda and T. Murayama and J. Matsumura and Y. Oba and R. Sonoda and K. Goto and K. Minoda and Y. Haraguchi and H. Suefuji and H. Miyagi and H. Kato and Tadashi Nakamura and Tsugihiro Nakamura and S. Lehman",
year = "2018",
month = nov,
doi = "10.1016/j.ihj.2018.09.001",
language = "English",
volume = "70",
pages = "828--835",
journal = "Indian Heart Journal",
issn = "0019-4832",
publisher = "Reed Elsevier India Pvt. Ltd.",
number = "6",
}
