Rituximab for treatment of refractory insulin autoimmune syndrome associated with non-Hodgkin B-cell lymphoma

Angela X. Chen, Ashanka Beligaswatte, Graham White, Morton G. Burt

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

Insulin autoimmune syndrome (IAS or Hirata's Disease) is a rare cause of spontaneous hypoglycaemia. In IAS, circulating autoantibodies bind endogenous insulin rendering insulin inactive. These complexes later dissociate in an unregulated manner resulting in hypoglycaemia.1 IAS is more common in the Asian population where it is associated with human leucocyte antigen‐DR4.1 In Caucasians, IAS has been reported with inflammatory rheumatologic disease and plasma cell disorders. We report a Caucasian patient with a typical presentation for IAS associated with non‐Hodgkin B‐cell lymphoma and the efficacy of rituximab therapy in this patient.
Original languageEnglish
Pages (from-to)230-232
Number of pages3
JournalClinical Endocrinology
Volume91
Issue number1
DOIs
Publication statusPublished - 22 Apr 2019

Keywords

  • glucose
  • glucose metabolism disorders
  • Hirata's disease
  • hypoglycaemia
  • insulin antibodies

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