Abstract
Insulin autoimmune syndrome (IAS or Hirata's Disease) is a rare cause of spontaneous hypoglycaemia. In IAS, circulating autoantibodies bind endogenous insulin rendering insulin inactive. These complexes later dissociate in an unregulated manner resulting in hypoglycaemia.1 IAS is more common in the Asian population where it is associated with human leucocyte antigen‐DR4.1 In Caucasians, IAS has been reported with inflammatory rheumatologic disease and plasma cell disorders. We report a Caucasian patient with a typical presentation for IAS associated with non‐Hodgkin B‐cell lymphoma and the efficacy of rituximab therapy in this patient.
Original language | English |
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Pages (from-to) | 230-232 |
Number of pages | 3 |
Journal | Clinical Endocrinology |
Volume | 91 |
Issue number | 1 |
DOIs | |
Publication status | Published - 22 Apr 2019 |
Keywords
- glucose
- glucose metabolism disorders
- Hirata's disease
- hypoglycaemia
- insulin antibodies