RNA dactyloscopy

Marta Magdalena Gabryelska; Eliza Wyszko; Jan Barciszewski

doi:10.18388/abp.2016_1341

RNA dactyloscopy

Marta Magdalena Gabryelska, Eliza Wyszko, Jan Barciszewski

Research output: Contribution to journal › Article › peer-review

3 Downloads (Pure)

Abstract

Despite the wealth of data on RNA secondary structure, conformational dynamics and tertiary structure in vitro and in vivo, predicting RNA biological activity in cellular environments remains difficult. Here, we present a comparison between in silico RNA fingerprinting and published experimental data that sheds light on efficient design of the hammerhead ribozyme molecules with a high intracellular efficiency. Our method, which we call RNA dactyloscopy, is a reliable tool for assessing the catalytic properties, modeling and design of RNA.

Original language	English
Pages (from-to)	785-787
Number of pages	3
Journal	Acta Biochimica Polonica
Volume	63
Issue number	4
DOIs	https://doi.org/10.18388/abp.2016_1341
Publication status	Published - 4 Mar 2016
Externally published	Yes

Keywords

Fingerprint
Hammerhead ribozyme
RNA tertiary structure

Access to Document

10.18388/abp.2016_1341Licence: CC BY-SA

Published versionFinal published version, 392 KBLicence: CC BY-SA

Cite this

@article{a723eb1d779645f182408327e145d6b1,

title = "RNA dactyloscopy",

abstract = "Despite the wealth of data on RNA secondary structure, conformational dynamics and tertiary structure in vitro and in vivo, predicting RNA biological activity in cellular environments remains difficult. Here, we present a comparison between in silico RNA fingerprinting and published experimental data that sheds light on efficient design of the hammerhead ribozyme molecules with a high intracellular efficiency. Our method, which we call RNA dactyloscopy, is a reliable tool for assessing the catalytic properties, modeling and design of RNA.",

keywords = "Fingerprint, Hammerhead ribozyme, RNA tertiary structure",

author = "Gabryelska, {Marta Magdalena} and Eliza Wyszko and Jan Barciszewski",

year = "2016",

month = mar,

day = "4",

doi = "10.18388/abp.2016_1341",

language = "English",

volume = "63",

pages = "785--787",

journal = "Acta Biochimica Polonica",

issn = "0001-527X",

number = "4",

}

TY - JOUR

T1 - RNA dactyloscopy

AU - Gabryelska, Marta Magdalena

AU - Wyszko, Eliza

AU - Barciszewski, Jan

PY - 2016/3/4

Y1 - 2016/3/4

N2 - Despite the wealth of data on RNA secondary structure, conformational dynamics and tertiary structure in vitro and in vivo, predicting RNA biological activity in cellular environments remains difficult. Here, we present a comparison between in silico RNA fingerprinting and published experimental data that sheds light on efficient design of the hammerhead ribozyme molecules with a high intracellular efficiency. Our method, which we call RNA dactyloscopy, is a reliable tool for assessing the catalytic properties, modeling and design of RNA.

AB - Despite the wealth of data on RNA secondary structure, conformational dynamics and tertiary structure in vitro and in vivo, predicting RNA biological activity in cellular environments remains difficult. Here, we present a comparison between in silico RNA fingerprinting and published experimental data that sheds light on efficient design of the hammerhead ribozyme molecules with a high intracellular efficiency. Our method, which we call RNA dactyloscopy, is a reliable tool for assessing the catalytic properties, modeling and design of RNA.

KW - Fingerprint

KW - Hammerhead ribozyme

KW - RNA tertiary structure

UR - http://www.scopus.com/inward/record.url?scp=85008226662&partnerID=8YFLogxK

U2 - 10.18388/abp.2016_1341

DO - 10.18388/abp.2016_1341

M3 - Article

C2 - 27904888

AN - SCOPUS:85008226662

SN - 0001-527X

VL - 63

SP - 785

EP - 787

JO - Acta Biochimica Polonica

JF - Acta Biochimica Polonica

IS - 4

ER -

RNA dactyloscopy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this