RNA dactyloscopy

Marta Magdalena Gabryelska, Eliza Wyszko, Jan Barciszewski

Research output: Contribution to journalArticlepeer-review

Abstract

Despite the wealth of data on RNA secondary structure, conformational dynamics and tertiary structure in vitro and in vivo, predicting RNA biological activity in cellular environments remains difficult. Here, we present a comparison between in silico RNA fingerprinting and published experimental data that sheds light on efficient design of the hammerhead ribozyme molecules with a high intracellular efficiency. Our method, which we call RNA dactyloscopy, is a reliable tool for assessing the catalytic properties, modeling and design of RNA.

Original languageEnglish
Pages (from-to)785-787
Number of pages3
JournalActa Biochimica Polonica
Volume63
Issue number4
DOIs
Publication statusPublished - 4 Mar 2016
Externally publishedYes

Keywords

  • Fingerprint
  • Hammerhead ribozyme
  • RNA tertiary structure

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