TY - JOUR
T1 - Role of copper and iron in methane oxidation and bacterial biopolymer accumulation
AU - Chidambarampadmavathy, Karthigeyan
AU - Obulisamy P, Karthikeyan
AU - Heimann, Kirsten Ruth
PY - 2015/5/1
Y1 - 2015/5/1
N2 - The aim of this review was to elucidate the role of copper and iron in regulating methane (CH4) oxidation and subsequent biopolymer (i.e. polyhydroxyalkanoate [PHA]) accumulation in methanotrophic bacteria. Specifically, the review emphasizes the "copper switch mechanism" that alters CH4 oxidizing enzyme activities, that is soluble- and particulate methane monooxygenases, in type II methanotrophic bacteria. Both copper and iron are essential nutrients and reports demonstrate that addition of either can improve PHA accumulation. However, based on analyses of available data, a major knowledge gap regarding a clear understanding of the interactive effects in regulating methane monooxygenase enzyme activities/gene expressions was identified in this review.
AB - The aim of this review was to elucidate the role of copper and iron in regulating methane (CH4) oxidation and subsequent biopolymer (i.e. polyhydroxyalkanoate [PHA]) accumulation in methanotrophic bacteria. Specifically, the review emphasizes the "copper switch mechanism" that alters CH4 oxidizing enzyme activities, that is soluble- and particulate methane monooxygenases, in type II methanotrophic bacteria. Both copper and iron are essential nutrients and reports demonstrate that addition of either can improve PHA accumulation. However, based on analyses of available data, a major knowledge gap regarding a clear understanding of the interactive effects in regulating methane monooxygenase enzyme activities/gene expressions was identified in this review.
KW - Bioreactor
KW - Copper
KW - Iron
KW - Methanotrophs
KW - Polyhydroxyalkaonate
UR - http://www.scopus.com/inward/record.url?scp=84929502994&partnerID=8YFLogxK
U2 - 10.1002/elsc.201400127
DO - 10.1002/elsc.201400127
M3 - Review article
SN - 1618-0240
VL - 15
SP - 387
EP - 399
JO - Engineering in Life Sciences
JF - Engineering in Life Sciences
IS - 4
ER -