Role of Glucocorticoids in Neutrophil and Endothelial Adhesion Molecule Expression and Function

Kevin D. Forsyth, Vivienne Talbot

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Glucocorticoids are very effective inhibitors of both the acute and chronic inflammatory response. In this study the hypothesis that glucocorticoids inhibit an early component of the inflammatory response, neutrophil adhesion to endothelium, by down-regulation of adhesion molecules on neutrophils or endothelium was examined. No effect of dexamethasone on neutrophil adhesion to endothelium or of antigen expression by neutrophils or endothelium was found. The mechanism of action of glucocorticoids in the inflammatory response is probably not mediated by alterations in adhesion molecules.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalMediators of Inflammation
Volume1
Issue number2
DOIs
Publication statusPublished - Jan 1992
Externally publishedYes

Keywords

  • Dexamethasone
  • Endothelial antigen expression
  • Glucocorticoids
  • Neutrophil adhesion

Fingerprint Dive into the research topics of 'Role of Glucocorticoids in Neutrophil and Endothelial Adhesion Molecule Expression and Function'. Together they form a unique fingerprint.

  • Cite this