Role of Glucocorticoids in Neutrophil and Endothelial Adhesion Molecule Expression and Function

Kevin D. Forsyth; Vivienne Talbot

doi:10.1155/S0962935192000176

Role of Glucocorticoids in Neutrophil and Endothelial Adhesion Molecule Expression and Function

Kevin D. Forsyth, Vivienne Talbot

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Abstract

Glucocorticoids are very effective inhibitors of both the acute and chronic inflammatory response. In this study the hypothesis that glucocorticoids inhibit an early component of the inflammatory response, neutrophil adhesion to endothelium, by down-regulation of adhesion molecules on neutrophils or endothelium was examined. No effect of dexamethasone on neutrophil adhesion to endothelium or of antigen expression by neutrophils or endothelium was found. The mechanism of action of glucocorticoids in the inflammatory response is probably not mediated by alterations in adhesion molecules.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Mediators of Inflammation
Volume	1
Issue number	2
DOIs	https://doi.org/10.1155/S0962935192000176
Publication status	Published - Jan 1992
Externally published	Yes

Keywords

Dexamethasone
Endothelial antigen expression
Glucocorticoids
Neutrophil adhesion

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10.1155/S0962935192000176Licence: CC BY

Published versionFinal published version, 2.1 MBLicence: CC BY

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Role of Glucocorticoids in Neutrophil and Endothelial Adhesion Molecule Expression and Function

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Keywords

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