Role of pulling direction in understanding the anisotropy of the resistance of proteins to force-induced mechanical unfolding

I. Jensen, D. Giri, S. Kumar

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Recent advances in single molecule experiments have made it possible to investigate the mechanical anisotropy of protein stability in greater detail. It has been found that proteins can exhibit a diverse range of responses when pulled in different directions. We review some of the experimental and numerical work related to the study of the resistance of proteins to force-induced mechanical unfolding. Based on model studies in the framework of statistical mechanics, we discuss the possible molecular origin of the anisotropy of protein resistance to unfolding.

Original languageEnglish
Pages (from-to)379-399
Number of pages21
JournalModern Physics Letters B
Volume24
Issue number4-5
DOIs
Publication statusPublished - 20 Feb 2010
Externally publishedYes

Keywords

  • Anisotropy in force direction
  • Exact enumeration
  • Force induced transitions
  • Lattice models
  • Mechanical unfolding
  • Polymers and bipolymers

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