TY - JOUR
T1 - Role of pulling direction in understanding the anisotropy of the resistance of proteins to force-induced mechanical unfolding
AU - Jensen, I.
AU - Giri, D.
AU - Kumar, S.
PY - 2010/2/20
Y1 - 2010/2/20
N2 - Recent advances in single molecule experiments have made it possible to investigate the mechanical anisotropy of protein stability in greater detail. It has been found that proteins can exhibit a diverse range of responses when pulled in different directions. We review some of the experimental and numerical work related to the study of the resistance of proteins to force-induced mechanical unfolding. Based on model studies in the framework of statistical mechanics, we discuss the possible molecular origin of the anisotropy of protein resistance to unfolding.
AB - Recent advances in single molecule experiments have made it possible to investigate the mechanical anisotropy of protein stability in greater detail. It has been found that proteins can exhibit a diverse range of responses when pulled in different directions. We review some of the experimental and numerical work related to the study of the resistance of proteins to force-induced mechanical unfolding. Based on model studies in the framework of statistical mechanics, we discuss the possible molecular origin of the anisotropy of protein resistance to unfolding.
KW - Anisotropy in force direction
KW - Exact enumeration
KW - Force induced transitions
KW - Lattice models
KW - Mechanical unfolding
KW - Polymers and bipolymers
UR - http://www.scopus.com/inward/record.url?scp=77951530917&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/ARC/DP0770705
U2 - 10.1142/S0217984910022469
DO - 10.1142/S0217984910022469
M3 - Article
AN - SCOPUS:77951530917
SN - 0217-9849
VL - 24
SP - 379
EP - 399
JO - Modern Physics Letters B
JF - Modern Physics Letters B
IS - 4-5
ER -