Role of pulling direction in understanding the energy landscape of proteins

R. Rajesh, D. Giri, I. Jensen, S. Kumar

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Single-molecule force spectroscopy provide details of the underlying energy surfaces of proteins which are essential to the understanding of their unfolding process. Recently, it has been observed experimentally that by pulling proteins in different directions relative to their secondary structure, one can gain a better understanding of the shape of the energy landscape. We consider simple lattice models which are anisotropic in nature to study the response of a force in unfolding of a polymer. Our analytical solution of the model, supported by extensive numerical calculations, reveal that the force temperature diagrams are very different depending on the direction of the applied force. We find that either unzipping or shearing kind transitions dominate the dynamics of the unfolding process depending solely on the direction of the applied force.

Original languageEnglish
Article number021905
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume78
Issue number2
DOIs
Publication statusPublished - 13 Aug 2008
Externally publishedYes

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