Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: A review

Paul I. Sia; John P.M. Wood; Glyn Chidlow; Shiwani Sharma; Jamie Craig; Robert Casson

doi:10.1111/ceo.12661

Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: A review

Paul I. Sia, John P.M. Wood, Glyn Chidlow, Shiwani Sharma, Jamie Craig, Robert Casson

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The nucleolus has emerged as a key regulator of cellular growth and the response to stress, in addition to its traditionally understood function in ribosome biogenesis. The association between nucleolar function and neurodegenerative disease is increasingly being explored. There is also recent evidence indicating that the nucleolus may well be crucial in the development of the eye. In this present review, the role of the nucleolus in retinal development as well as in neurodegeneration with an emphasis on the retina is discussed.

Original language	English
Pages (from-to)	188-195
Number of pages	8
Journal	Clinical and Experimental Ophthalmology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1111/ceo.12661
Publication status	Published - Apr 2016

Keywords

nucleolus
neurodegenerative diseases
retina
ribosomes

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