Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: A review

Paul I. Sia, John P.M. Wood, Glyn Chidlow, Shiwani Sharma, Jamie Craig, Robert Casson

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The nucleolus has emerged as a key regulator of cellular growth and the response to stress, in addition to its traditionally understood function in ribosome biogenesis. The association between nucleolar function and neurodegenerative disease is increasingly being explored. There is also recent evidence indicating that the nucleolus may well be crucial in the development of the eye. In this present review, the role of the nucleolus in retinal development as well as in neurodegeneration with an emphasis on the retina is discussed.

    Original languageEnglish
    Pages (from-to)188-195
    Number of pages8
    JournalClinical and Experimental Ophthalmology
    Volume44
    Issue number3
    DOIs
    Publication statusPublished - Apr 2016

    Keywords

    • nucleolus
    • neurodegenerative diseases
    • retina
    • ribosomes

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