Abstract
Experimental and clinical studies conducted over the last 30 years have investigated the effects of folic acid, also called vitamin B9, on cardiometabolic risk factors (i.e. hypertension, hyperglycaemia, and dyslipidaemia), pathophysiological mechanisms (i.e. insulin resistance and homocysteine), and relevant clinical outcomes in patients with type 2 diabetes, a leading cause of death and disability worldwide. This chapter discusses the current knowledge regarding the factors involved in the onset and progression of type 2 diabetes, the chemistry and biology of folic acid and related nutritional considerations, the effects of folic acid interventions on individual cardiometabolic risk factors and the clinical end points in patients with type 2 diabetes, and the future research directions in this area.
| Original language | English |
|---|---|
| Title of host publication | Organic Acids in Diabetes |
| Subtitle of host publication | Applications and Mechanisms |
| Editors | Md. Shahidul Islam |
| Place of Publication | Boca Raton, Florida |
| Publisher | CRC Press |
| Chapter | 1 |
| Pages | 1-21 |
| Number of pages | 21 |
| ISBN (Electronic) | 978-1-003-49580-2 |
| ISBN (Print) | 978-1-032-80165-0, 978-1-032-80166-7 |
| DOIs | |
| Publication status | Published - 29 Oct 2025 |
Keywords
- folic acid
- vitamin B9
- cardiometabolic
- hypertension
- hyperglycaemia
- dyslipidaemia
- insulin resistance
- homocysteine
- pathophysiological
- type 2 diabetes