TY - JOUR
T1 - ROS-responsive copolymer micelles for inflammation triggered delivery of ibuprofen
AU - Quek, Jing Yang
AU - Bright, Richard
AU - Dabare, P. R.L.
AU - Vasilev, Krasimir
PY - 2022/9
Y1 - 2022/9
N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of pain, inflammation and fever. However, most NSAIDs are poorly water soluble, making it difficult to be administered thus high doses are required to reach the intended therapeutic effect, resulting in associated side effects. In this study, ROS-responsive micellar systems based on a block copolymer consisting of methylpropyl thioether (MTPA) and N'N-dimethylacrylamide was developed and loaded with ibuprofen (IBU). Using lipopolysaccharide activated RAW 264.7 macrophage like cells, we demonstrated that IBU was released from the copolymer, specifically in the presence of ROS. Interestingly, IBU encapsulated in ROS-responsive nanoparticles exhibited greater anti-inflammatory potency compared to its free form. The work highlights the potential of the ROS-responsive micellar system developed in this work to be used as carrier of NSAIDs for the treatment of relevant inflammatory conditions.
AB - Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of pain, inflammation and fever. However, most NSAIDs are poorly water soluble, making it difficult to be administered thus high doses are required to reach the intended therapeutic effect, resulting in associated side effects. In this study, ROS-responsive micellar systems based on a block copolymer consisting of methylpropyl thioether (MTPA) and N'N-dimethylacrylamide was developed and loaded with ibuprofen (IBU). Using lipopolysaccharide activated RAW 264.7 macrophage like cells, we demonstrated that IBU was released from the copolymer, specifically in the presence of ROS. Interestingly, IBU encapsulated in ROS-responsive nanoparticles exhibited greater anti-inflammatory potency compared to its free form. The work highlights the potential of the ROS-responsive micellar system developed in this work to be used as carrier of NSAIDs for the treatment of relevant inflammatory conditions.
KW - Anti-inflammatory
KW - Ibuprofen
KW - Inflammation triggered drug delivery
KW - Polymeric micelles
KW - ROS-responsive
UR - http://www.scopus.com/inward/record.url?scp=85131425583&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/ARC/DP180101254
UR - http://purl.org/au-research/grants/NHMRC/1194466
UR - http://purl.org/au-research/grants/NHMRC/GNT1122726
U2 - 10.1016/j.colsurfb.2022.112590
DO - 10.1016/j.colsurfb.2022.112590
M3 - Article
C2 - 35660744
AN - SCOPUS:85131425583
SN - 0927-7765
VL - 217
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
M1 - 112590
ER -