Safety and Tolerability of Angiotensin Receptor-Neprilysin Inhibitor Initiation in High-Risk Acute Myocardial Infarction Relative to Care Setting: A Subgroup Analysis of the PARADISE-MI Trial

Carmine G. De Pasquale, Brian Claggett, Karola Jering, John J.V. McMurray, Douglas Mann, Zi Michael Miao, Christopher B. Granger, Lars Køber, Aldo P. Maggioni, Jean-Lucien Rouleau, Scott D. Solomon, Philippe Gabriel Steg, Peter Van Der Meer, Eugene Braunwald, Marc A. Pfeffer

Research output: Contribution to journalArticlepeer-review

Abstract

The initiation of disease-modifying pharmacological agents that also lower blood pressure in the period immediately after acute myocardial infarction (AMI)can be challenging. For sacubitril/valsartan, the extrapolation of safety and tolerability evidence to the acute illness setting is limited by the run-in phase of seminal outcome trials and their target population of patients with ambulatory chronic disease.
Original languageEnglish
Pages (from-to)e011393
Number of pages4
JournalCirculation: Heart Failure
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 2024

Keywords

  • chronic disease
  • heart failure
  • myocardial infarction
  • physicians
  • valsartan

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