Safety of nurse‐ and self‐administered paediatric outpatient parenteral antimicrobial therapy

Shanthy Sriskandarajah, Brett Ritchie, Janet K. Sluggett, Jodie G. Hobbs, Karen J. Reynolds

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
26 Downloads (Pure)


This study aimed to compare and contrast the safety and efficacy of nurse‐ and self-administered paediatric outpatient parenteral antimicrobial therapy (OPAT) models of care and to identify clinical factors associated with documented adverse events (AEs). A total of 100 OPAT episodes among children aged between 1 month and 18 years who were discharged from hospital and who received continuous 24 h intravenous antimicrobial therapy at home via an elastomeric infusion device were included. All documented AEs from the case notes were reviewed by a paediatrician and classified as either major or minor. Multivariable logistic regression was used to determine associations between clinical factors and any AE. A total of 86 patients received 100 treatment OPAT episodes (49 self‐administered, 51 nurse administered). The most commonly prescribed antimicrobial via continuous infusion was ceftazidime (25 episodes). Overall, an AE was recorded for 27 (27%) OPAT episodes. Major AEs was recorded for 15 episodes and minor AEs were reported in 14 episodes. The odds of an AE was increased in episodes with self‐administration (adjusted odds ratio (aOR) 6.25, 95% confidence interval (CI) 1.44–27.15) and where the duration of vascular access was >14 days (aOR 1.08, 95%CI 1.01–1.15). Our findings suggest minor AEs may be more frequently reported when intravenous antimicrobials are self‐administered via 24 h continuous infusions.

Original languageEnglish
Article number761
Number of pages11
Issue number11
Publication statusPublished - Nov 2020


  • Adverse events
  • Children
  • Infusion pumps
  • Outpatient parenteral antimicrobial therapy
  • Safety


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