Scoping review of chronic rhinosinusitis proteomics

Stephen Shih Teng Kao, Ahmed Bassiouni, Mahnaz Ramezanpour, Nusha Chegeni, Alex D. Colella, Timothy K. Chataway, Peter John Wormald, Sarah Vreugde, Alkis James Psaltis

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Background: Progressive advances in proteomic technology has improved our understanding of the chronic rhinosinusitis (CRS) pathogenesis and endotypes. This scoping review aims to present a comprehensive and descriptive analysis of nasal mucosa and mucus proteome of CRS patients.Methodology: Studies investigating the proteome of nasal mucosa and mucus from healthy and CRS patients via mass spectro-metry were included. Critical appraisal of methodological quality was conducted with extraction of protein lists. Gene set enrich-ment analysis (GSEA) was performed on studies including CRS patients. Results: 2962 proteins were identified in the 21 studies included in this review. Eleven studies investigated the nasal mucus proteome and ten studies investigated the nasal mucosa proteome. Studies demonstrated heterogeneity in patients, sampling and mass spectrometry methodology. Samples from CRS patients suggested a trend in enrichment of immune system and pro-grammed cell death pathways. Increased expression of proteins involved in cellular components including the cytoskeleton and adherens junctions was also present in CRS. Conclusions: Alterations in the healthy sinonasal proteome may lead to the increased immunological, metabolic and tissue remo-deling processes observed in CRS. However, it is difficult to draw significant conclusions from the GSEA due to the heterogeneity present in the limited literature available. These findings allow us to direct further research to better understand CRS pathogenesis and its endotypes.

Original languageEnglish
Pages (from-to)418-429
Number of pages12
JournalRhinology
Volume58
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • Chrhronic rhinosinusitis
  • Mass spectrometry
  • Mucus
  • Proteomics
  • Scoping review

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