TY - JOUR
T1 - Screening of Cytotoxic Drugs for Residual Bone Marrow Damage
AU - Trainor, K. J.
AU - Morley, A. A.
PY - 1976/12
Y1 - 1976/12
N2 - Several cytotoxic drugs were tested for their ability to produce permanent residual damage to the bone marrow. A short course of the drug was given to BALB/c female mice, and the numbers of various types of bone marrow cells were determined at least two months later. Evidence of residual damage was found after administration of busulfan and 1, 3-bis(chloroethyl)-1-nitrosourea, but not after administration of cyclophosphamide, 5-fluorouracil, 6-mercaptopurine, methotrexate, or vinblastine.
AB - Several cytotoxic drugs were tested for their ability to produce permanent residual damage to the bone marrow. A short course of the drug was given to BALB/c female mice, and the numbers of various types of bone marrow cells were determined at least two months later. Evidence of residual damage was found after administration of busulfan and 1, 3-bis(chloroethyl)-1-nitrosourea, but not after administration of cyclophosphamide, 5-fluorouracil, 6-mercaptopurine, methotrexate, or vinblastine.
UR - http://www.scopus.com/inward/record.url?scp=0017029137&partnerID=8YFLogxK
U2 - 10.1093/jnci/57.6.1237
DO - 10.1093/jnci/57.6.1237
M3 - Article
C2 - 1003558
AN - SCOPUS:0017029137
SN - 0027-8874
VL - 57
SP - 1237
EP - 1239
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 6
ER -
