Screening of Cytotoxic Drugs for Residual Bone Marrow Damage

K. J. Trainor, A. A. Morley

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Several cytotoxic drugs were tested for their ability to produce permanent residual damage to the bone marrow. A short course of the drug was given to BALB/c female mice, and the numbers of various types of bone marrow cells were determined at least two months later. Evidence of residual damage was found after administration of busulfan and 1, 3-bis(chloroethyl)-1-nitrosourea, but not after administration of cyclophosphamide, 5-fluorouracil, 6-mercaptopurine, methotrexate, or vinblastine.

Original languageEnglish
Pages (from-to)1237-1239
Number of pages3
JournalJournal of the National Cancer Institute
Issue number6
Publication statusPublished - Dec 1976
Externally publishedYes


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