Secondary metabolites from microorganisms isolated from marine sponges from 2000 to 2012

The continuously developing resistance of pathogenic bacteria, the reemergence of viral diseases, and cancers that are still incurable make us redouble our efforts to find cures to alleviate human vulnerabilities. The introduction of new drugs is crucial, as older antibiotics and drugs begin to lose their efficacy. Rationally designed drugs have made inroads into the pharmaceutical industry, but natural products continue to introduce the chemical diversity required to maintain a contribution of around 60% of the drugs, directly or after chemical modification, which are available in the market (Newman and Cragg, 2007). Microbial natural products contribute more than 40% of new chemical entities reported between 1981 and 2010 (Newman et al., 2003; Baltz et al., 2005; Koehn and Carter, 2005; Fisher, 2014).