Selection of Gentamicin-Resistant Variants of Pseudomonas aeruginosa in the Rat Cornea

Paul R. Badenoch, Douglas J. Coster

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Pseudomonas aeruginosa often persists in ocular infections despite intensive antimicrobial therapy. In this study, gentamicin-resistant small colony variants (SCV) were selected in vitro from three gentamicin-susceptible Pseudomonas isolates by incubation with antibiotic. In the rat comea, SCV were selected from two of these strains by administration of gentamicin either topically or intravenously. The selection of resistant variants may be a contributing factor in the persistence and reactivation frequently associated with ocular Pseudomonas infections.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalJOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
Volume5
Issue number1
DOIs
Publication statusPublished - 1 Jan 1989
Externally publishedYes

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