Abstract
Pseudomonas aeruginosa often persists in ocular infections despite intensive antimicrobial therapy. In this study, gentamicin-resistant small colony variants (SCV) were selected in vitro from three gentamicin-susceptible Pseudomonas isolates by incubation with antibiotic. In the rat comea, SCV were selected from two of these strains by administration of gentamicin either topically or intravenously. The selection of resistant variants may be a contributing factor in the persistence and reactivation frequently associated with ocular Pseudomonas infections.
| Original language | English |
|---|---|
| Pages (from-to) | 19-25 |
| Number of pages | 7 |
| Journal | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1989 |
| Externally published | Yes |