TY - JOUR
T1 - Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism
T2 - effects on theophylline.
AU - Robson, RA
AU - Miners, JO
AU - Birkett, DJ
PY - 1988/3
Y1 - 1988/3
N2 - Nine healthy male volunteers were studied to assess the possibility of an interaction between theophylline and nifedipine or verapamil using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly with and without nifedipine 20 mg 12 hourly and verapamil 80 mg 8 hourly. Nifedipine treatment reduced mean total theophylline clearance by 9%, due to decreased clearances via 1‐ and 3‐ demethylation. Verapamil treatment reduced mean total theophylline clearance by 14%, due to decreased clearances via 1‐ and 3‐ demethylation and 8‐hydroxylation. Verapamil and nifedipine at usual clinical doses are unlikely to cause clinically significant changes in theophylline disposition. 1988 The British Pharmacological Society
AB - Nine healthy male volunteers were studied to assess the possibility of an interaction between theophylline and nifedipine or verapamil using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly with and without nifedipine 20 mg 12 hourly and verapamil 80 mg 8 hourly. Nifedipine treatment reduced mean total theophylline clearance by 9%, due to decreased clearances via 1‐ and 3‐ demethylation. Verapamil treatment reduced mean total theophylline clearance by 14%, due to decreased clearances via 1‐ and 3‐ demethylation and 8‐hydroxylation. Verapamil and nifedipine at usual clinical doses are unlikely to cause clinically significant changes in theophylline disposition. 1988 The British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0023897849&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2125.1988.tb03319.x
DO - 10.1111/j.1365-2125.1988.tb03319.x
M3 - Article
C2 - 3358901
AN - SCOPUS:0023897849
SN - 0306-5251
VL - 25
SP - 397
EP - 400
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 3
ER -