Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline.

RA Robson, JO Miners, DJ Birkett

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Nine healthy male volunteers were studied to assess the possibility of an interaction between theophylline and nifedipine or verapamil using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly with and without nifedipine 20 mg 12 hourly and verapamil 80 mg 8 hourly. Nifedipine treatment reduced mean total theophylline clearance by 9%, due to decreased clearances via 1‐ and 3‐ demethylation. Verapamil treatment reduced mean total theophylline clearance by 14%, due to decreased clearances via 1‐ and 3‐ demethylation and 8‐hydroxylation. Verapamil and nifedipine at usual clinical doses are unlikely to cause clinically significant changes in theophylline disposition. 1988 The British Pharmacological Society

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 1988
Externally publishedYes

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