Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes

Michelle J. Pisani; Daniel K. Weber; Kirsten Ruth Heimann; Grant Collins; Richard Richard Keene

doi:10.1039/c004922k

Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes

Michelle J. Pisani
, Daniel K. Weber
, Kirsten Ruth Heimann
, Grant Collins
, Richard Richard Keene

Flinders University

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The lipophilic ligand-bridged dinuclear cation Rubb₁₆ is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.

Original language	English
Pages (from-to)	393-396
Number of pages	4
Journal	Metallomics
Volume	2
Issue number	6
DOIs	https://doi.org/10.1039/c004922k
Publication status	Published - Jun 2010

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10.1039/c004922k

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@article{6647544f439a48a3881f3ec7bb55eafb,

title = "Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes",

abstract = "The lipophilic ligand-bridged dinuclear cation Rubb16 is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.",

author = "Pisani, \{Michelle J.\} and Weber, \{Daniel K.\} and Heimann, \{Kirsten Ruth\} and Grant Collins and Keene, \{Richard Richard\}",

year = "2010",

month = jun,

doi = "10.1039/c004922k",

language = "English",

volume = "2",

pages = "393--396",

journal = "Metallomics",

issn = "1756-5901",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes

AU - Pisani, Michelle J.

AU - Weber, Daniel K.

AU - Heimann, Kirsten Ruth

AU - Collins, Grant

AU - Keene, Richard Richard

PY - 2010/6

Y1 - 2010/6

N2 - The lipophilic ligand-bridged dinuclear cation Rubb16 is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.

AB - The lipophilic ligand-bridged dinuclear cation Rubb16 is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.

UR - https://www.scopus.com/pages/publications/77956074303

U2 - 10.1039/c004922k

DO - 10.1039/c004922k

M3 - Article

SN - 1756-5901

VL - 2

SP - 393

EP - 396

JO - Metallomics

JF - Metallomics

IS - 6

ER -

Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes

Abstract

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