Selenium-rich foods: a promising approach to colorectal cancer prevention

Ying Hu, McIntosh GH, Young GP

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    Selenium (Se), an essential trace element, has also been identified as an anticarcinogenic agent, with supporting evidence from epidemiological studies, clinical intervention trials, preclinical intervention studies (animal cancer models) and cell culture studies. Natural organic and inorganic sources of Se as well as synthetic organoselenium compounds have been shown to be effective; safety and efficacy factors favour the organic forms. Intakes that are several fold that purported to meet nutritional requirements (adult recommend dietary allowance - 55 μg Se/day) are associated with reductions in cancer risk, but are not currently met by most diets, unless Se-rich foods are included. Further clinical studies and development of tools for speciating Se in foods will enable progress to be made in determining desirable Se forms and foods with respect to providing safe and effective ways of reducing cancer risk.

    Original languageEnglish
    Pages (from-to)165-172
    Number of pages8
    JournalCurrent Pharmaceutical Biotechnology
    Volume13
    Issue number1
    Early online date2012
    DOIs
    Publication statusPublished - Jan 2012

    Keywords

    • Chemoprevention
    • Colorectal cancer
    • Health benefit
    • Selenium
    • Selenium-rich foods

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