Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine

Mehfuz Zaman, Mariusz Skwarczynski, Jessica M. Malcolm, Carl N. Urbani, Zhongfan Jia, Michael R. Batzloff, Michael F. Good, Michael J. Monteiro, Istvan Toth

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51 Citations (Scopus)

Abstract

Infection with Streptococcus pyogenes, commonly known as group A Streptococcus (GAS), is responsible for acute and postinfectious complications, including rheumatic fever and rheumatic heart disease (RHD). RHD is a global health burden, and Australia's indigenous population has one of the highest incidences of RHD worldwide. A potential peptide (J14) vaccine candidate has been previously identified from the C-terminal region of the M protein. However, such peptide-based vaccine development is hampered by a lack of carriers and adjuvants suitable for humans use. We have developed a fully synthetic peptide subunit vaccine candidate based on polyacrylate dendritic polymer. Intranasal administration of this nanoparticulate construct without additional adjuvant induced J14-specific IgG, which was also capable of in vitro opsonization of GAS, highlighting the potential of self-adjuvanting polyacrylate nanoparticle-based construct as a peptide vaccine delivery platform that may afford promising opportunities for treating systemic GAS infection. From the Clinical Editor: Polyacrylate dendrimers offer a unique approach to a nasally administered vaccine for addressing rheumatic heart disease. This paper describes the delivery of the J14 peptide, a C-terminal derivative of M-protein in group A Streptococcus.

Original languageEnglish
Pages (from-to)168-173
Number of pages6
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

Keywords

  • Dendrimer
  • Group A Streptococcus
  • Intranasal immunization
  • Self-adjuvanting vaccine
  • Self-assembled nanoparticles

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    Zaman, M., Skwarczynski, M., Malcolm, J. M., Urbani, C. N., Jia, Z., Batzloff, M. R., Good, M. F., Monteiro, M. J., & Toth, I. (2011). Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine. Nanomedicine: Nanotechnology, Biology, and Medicine, 7(2), 168-173. https://doi.org/10.1016/j.nano.2010.10.002