Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

Tzu Yu Liu, Waleed M. Hussein, Zhongfan Jia, Zyta M. Ziora, Nigel A.J. McMillan, Michael J. Monteiro, Istvan Toth, Mariusz Skwarczynski

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75 Citations (Scopus)

Abstract

Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.

Original languageEnglish
Pages (from-to)2798-2806
Number of pages9
JournalBiomacromolecules
Volume14
Issue number8
DOIs
Publication statusPublished - 12 Aug 2013
Externally publishedYes

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  • Cite this

    Liu, T. Y., Hussein, W. M., Jia, Z., Ziora, Z. M., McMillan, N. A. J., Monteiro, M. J., Toth, I., & Skwarczynski, M. (2013). Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer. Biomacromolecules, 14(8), 2798-2806. https://doi.org/10.1021/bm400626w