Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

Tzu Yu Liu; Waleed M. Hussein; Zhongfan Jia; Zyta M. Ziora; Nigel A.J. McMillan; Michael J. Monteiro; Istvan Toth; Mariusz Skwarczynski

doi:10.1021/bm400626w

Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

Tzu Yu Liu, Waleed M. Hussein, Zhongfan Jia, Zyta M. Ziora, Nigel A.J. McMillan, Michael J. Monteiro, Istvan Toth, Mariusz Skwarczynski

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.

Original language	English
Pages (from-to)	2798-2806
Number of pages	9
Journal	Biomacromolecules
Volume	14
Issue number	8
DOIs	https://doi.org/10.1021/bm400626w
Publication status	Published - 12 Aug 2013
Externally published	Yes

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AU - Liu, Tzu Yu

AU - Hussein, Waleed M.

AU - Jia, Zhongfan

AU - Ziora, Zyta M.

AU - McMillan, Nigel A.J.

AU - Monteiro, Michael J.

AU - Toth, Istvan

AU - Skwarczynski, Mariusz

PY - 2013/8/12

Y1 - 2013/8/12

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AB - Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.

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JO - Biomacromolecules

JF - Biomacromolecules

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Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

Abstract

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