Abstract
Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.
Original language | English |
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Pages (from-to) | 2798-2806 |
Number of pages | 9 |
Journal | Biomacromolecules |
Volume | 14 |
Issue number | 8 |
DOIs | |
Publication status | Published - 12 Aug 2013 |
Externally published | Yes |