Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

Tzu Yu Liu; Waleed M. Hussein; Zhongfan Jia; Zyta M. Ziora; Nigel A.J. McMillan; Michael J. Monteiro; Istvan Toth; Mariusz Skwarczynski

doi:10.1021/bm400626w

Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

Tzu Yu Liu
, Waleed M. Hussein
, Zhongfan Jia
, Zyta M. Ziora
, Nigel A.J. McMillan
, Michael J. Monteiro
, Istvan Toth
, Mariusz Skwarczynski

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.

Original language	English
Pages (from-to)	2798-2806
Number of pages	9
Journal	Biomacromolecules
Volume	14
Issue number	8
DOIs	https://doi.org/10.1021/bm400626w
Publication status	Published - 12 Aug 2013
Externally published	Yes

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10.1021/bm400626wLicence: In Copyright

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title = "Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer",

abstract = "Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.",

author = "Liu, \{Tzu Yu\} and Hussein, \{Waleed M.\} and Zhongfan Jia and Ziora, \{Zyta M.\} and McMillan, \{Nigel A.J.\} and Monteiro, \{Michael J.\} and Istvan Toth and Mariusz Skwarczynski",

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T1 - Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

AU - Liu, Tzu Yu

AU - Hussein, Waleed M.

AU - Jia, Zhongfan

AU - Ziora, Zyta M.

AU - McMillan, Nigel A.J.

AU - Monteiro, Michael J.

AU - Toth, Istvan

AU - Skwarczynski, Mariusz

PY - 2013/8/12

Y1 - 2013/8/12

N2 - Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.

AB - Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.

UR - https://www.scopus.com/pages/publications/84881570194

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M3 - Article

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AN - SCOPUS:84881570194

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EP - 2806

JO - Biomacromolecules

JF - Biomacromolecules

IS - 8

ER -

Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

Abstract

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