Self-Catalyzed Degradation of Linear Cationic Poly(2-dimethylaminoethyl acrylate) in Water

Nghia P. Truong, Zhongfan Jia, Melinda Burges, Nigel A.J. McMillan, Michael J. Monteiro

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

We report the synthesis of a low cytotoxic polycation that maintains its cationic strength for well over a few hours then degrades into a benign polymer with nontoxic byproducts. Well-defined poly(2-dimethylaminoethyl acrylate) (PDMAEA) of five different molecular weights prepared using reversible addition-fragmentation chain transfer (RAFT) "living" radical polymerization degrades slowly over 200 h (∼8 days). As this degradation is independent of both the polymer molecular weight and solution pH, it is consistent with a self-catalyzed hydrolysis process without the need for an internal or external degradation trigger. In addition, the polymer shows little or no cytotoxicity to HeLa cells for the molecular weights of 5600 and below, even at very high polymer concentrations (equivalent to a nitrogen/phosphorus ratio of 200). Therefore, at sufficiently low molecular weights this polymer has the essential attributes (i.e., ability to autodegradable and low toxicity) for a delivery carrier suitable for DNA or siRNA.

Original languageEnglish
Pages (from-to)1876-1882
Number of pages7
JournalBiomacromolecules
Volume12
Issue number5
DOIs
Publication statusPublished - 9 May 2011
Externally publishedYes

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