Sensitivity of lymphocytes from patients with cancer to X‐ and ultraviolet radiation

Robert Kutlaca; Ram Seshadri; Alexander A. Morley

doi:10.1002/1097-0142(19841215)54:12<2952::AID-CNCR2820541223>3.0.CO;2-W

Sensitivity of lymphocytes from patients with cancer to X‐ and ultraviolet radiation

Robert Kutlaca, Ram Seshadri, Alexander A. Morley

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

It has been suggested that radiation sensitivity may be increased in certain patients with cancer. Using a high‐efficiency limiting dilution cloning technique, the sensitivity to x‐ and ultraviolet (UV)‐radiation of lymphocytes from untreated patients with cancer to that of age‐matched controls was compared. Sensitivity to x‐radiation in 19 patients with carcinoma and 10 with lymphoma, and sensitivity to UV‐radiation in 8 patients with carcinoma and 4 with lymphoma were studied. The proportion of unirradiated lymphocytes forming clones was significantly lower in patients with cancer, particularly lymphoma, but there was no suggestion of increased sensitivity to either x‐ or UV‐radiation in any of the patients studied.

Original language	English
Pages (from-to)	2952-2955
Number of pages	4
Journal	Cancer
Volume	54
Issue number	12
DOIs	https://doi.org/10.1002/1097-0142(19841215)54:12<2952::AID-CNCR2820541223>3.0.CO;2-W
Publication status	Published - 15 Dec 1984
Externally published	Yes

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10.1002/1097-0142(19841215)54:12<2952::AID-CNCR2820541223>3.0.CO;2-WLicence: In Copyright

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AU - Kutlaca, Robert

AU - Seshadri, Ram

AU - Morley, Alexander A.

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Y1 - 1984/12/15

N2 - It has been suggested that radiation sensitivity may be increased in certain patients with cancer. Using a high‐efficiency limiting dilution cloning technique, the sensitivity to x‐ and ultraviolet (UV)‐radiation of lymphocytes from untreated patients with cancer to that of age‐matched controls was compared. Sensitivity to x‐radiation in 19 patients with carcinoma and 10 with lymphoma, and sensitivity to UV‐radiation in 8 patients with carcinoma and 4 with lymphoma were studied. The proportion of unirradiated lymphocytes forming clones was significantly lower in patients with cancer, particularly lymphoma, but there was no suggestion of increased sensitivity to either x‐ or UV‐radiation in any of the patients studied.

AB - It has been suggested that radiation sensitivity may be increased in certain patients with cancer. Using a high‐efficiency limiting dilution cloning technique, the sensitivity to x‐ and ultraviolet (UV)‐radiation of lymphocytes from untreated patients with cancer to that of age‐matched controls was compared. Sensitivity to x‐radiation in 19 patients with carcinoma and 10 with lymphoma, and sensitivity to UV‐radiation in 8 patients with carcinoma and 4 with lymphoma were studied. The proportion of unirradiated lymphocytes forming clones was significantly lower in patients with cancer, particularly lymphoma, but there was no suggestion of increased sensitivity to either x‐ or UV‐radiation in any of the patients studied.

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JO - Cancer

JF - Cancer

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Sensitivity of lymphocytes from patients with cancer to X‐ and ultraviolet radiation

Abstract

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