Sensitivity of lymphocytes from patients with cancer to X‐ and ultraviolet radiation

Robert Kutlaca, Ram Seshadri, Alexander A. Morley

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

It has been suggested that radiation sensitivity may be increased in certain patients with cancer. Using a high‐efficiency limiting dilution cloning technique, the sensitivity to x‐ and ultraviolet (UV)‐radiation of lymphocytes from untreated patients with cancer to that of age‐matched controls was compared. Sensitivity to x‐radiation in 19 patients with carcinoma and 10 with lymphoma, and sensitivity to UV‐radiation in 8 patients with carcinoma and 4 with lymphoma were studied. The proportion of unirradiated lymphocytes forming clones was significantly lower in patients with cancer, particularly lymphoma, but there was no suggestion of increased sensitivity to either x‐ or UV‐radiation in any of the patients studied.

Original languageEnglish
Pages (from-to)2952-2955
Number of pages4
JournalCancer
Volume54
Issue number12
DOIs
Publication statusPublished - 15 Dec 1984
Externally publishedYes

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