Separate populations of opioid containing neurons in the guinea-pig intestine

M. Costa; J. B. Furness; A. C. Cuello

doi:10.1016/0143-4179(85)90050-2

Separate populations of opioid containing neurons in the guinea-pig intestine

M. Costa, J. B. Furness, A. C. Cuello

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Abstract

Double staining immunofluorescence techniques were applied to investigate the co-existence of enkephalin, dynorphin and vasoactive intestinal peptide immunoreactivity in the guinea-pig enteric nervous system. Segments of guinea-pig small intestine were incubated for 24h in a culture medium with colchicine. Several subpopulations with overlapping immunoreactivities were found, i.e. neurons with enkephalin and vasoactive intestinal peptide, with enkephalin and dynorphin and with all three neuropeptides. It is probable that subpopulations with dynorphin and vasoactive intestinal peptide and with each neuropeptide only are also present. These subpopulations of enteric neurons with multiple neurochemical subcoding are likely to have different connections and functions.

Original language	English
Pages (from-to)	445-448
Number of pages	4
Journal	Neuropeptides
Volume	5
Issue number	4-6
DOIs	https://doi.org/10.1016/0143-4179(85)90050-2
Publication status	Published - Feb 1985

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title = "Separate populations of opioid containing neurons in the guinea-pig intestine",

abstract = "Double staining immunofluorescence techniques were applied to investigate the co-existence of enkephalin, dynorphin and vasoactive intestinal peptide immunoreactivity in the guinea-pig enteric nervous system. Segments of guinea-pig small intestine were incubated for 24h in a culture medium with colchicine. Several subpopulations with overlapping immunoreactivities were found, i.e. neurons with enkephalin and vasoactive intestinal peptide, with enkephalin and dynorphin and with all three neuropeptides. It is probable that subpopulations with dynorphin and vasoactive intestinal peptide and with each neuropeptide only are also present. These subpopulations of enteric neurons with multiple neurochemical subcoding are likely to have different connections and functions.",

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AB - Double staining immunofluorescence techniques were applied to investigate the co-existence of enkephalin, dynorphin and vasoactive intestinal peptide immunoreactivity in the guinea-pig enteric nervous system. Segments of guinea-pig small intestine were incubated for 24h in a culture medium with colchicine. Several subpopulations with overlapping immunoreactivities were found, i.e. neurons with enkephalin and vasoactive intestinal peptide, with enkephalin and dynorphin and with all three neuropeptides. It is probable that subpopulations with dynorphin and vasoactive intestinal peptide and with each neuropeptide only are also present. These subpopulations of enteric neurons with multiple neurochemical subcoding are likely to have different connections and functions.

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Separate populations of opioid containing neurons in the guinea-pig intestine

Abstract

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