Separate populations of opioid containing neurons in the guinea-pig intestine

M. Costa, J. B. Furness, A. C. Cuello

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)

    Abstract

    Double staining immunofluorescence techniques were applied to investigate the co-existence of enkephalin, dynorphin and vasoactive intestinal peptide immunoreactivity in the guinea-pig enteric nervous system. Segments of guinea-pig small intestine were incubated for 24h in a culture medium with colchicine. Several subpopulations with overlapping immunoreactivities were found, i.e. neurons with enkephalin and vasoactive intestinal peptide, with enkephalin and dynorphin and with all three neuropeptides. It is probable that subpopulations with dynorphin and vasoactive intestinal peptide and with each neuropeptide only are also present. These subpopulations of enteric neurons with multiple neurochemical subcoding are likely to have different connections and functions.

    Original languageEnglish
    Pages (from-to)445-448
    Number of pages4
    JournalNeuropeptides
    Volume5
    Issue number4-6
    DOIs
    Publication statusPublished - Feb 1985

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