Serological responses following influenza A H1N1 2009 infection in adults

Sophia Tan; David Gordon; Y. Honda-Okubo; Nikolai Petrovsky; Peter Phillips; Sandra Huddleston; Tania Sadlon

doi:10.1016/j.jinf.2011.03.002

Serological responses following influenza A H1N1 2009 infection in adults

Sophia Tan, David Gordon, Y. Honda-Okubo, Nikolai Petrovsky, Peter Phillips, Sandra Huddleston, Tania Sadlon

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine the humoral immune response to influenza A H1N1 2009 and cross reactivity against seasonal H1N1 and H3N2 strains. Methods: Baseline and convalescent sera from 88 subjects with confirmed H1N1 2009 were screened for serological responses by HAI assay. Results: Protective antibody titres to H1N1 2009 were present in 87% post-infection, but varied with age, sex and pregnancy. Some cross reactivity with seasonal influenza strains was observed. Conclusions: Females and pregnant subjects had an attenuated immune response to H1N1 2009 in comparison to the rest of the study population. Antibodies from the serum of H1N1 2009 infected subjects cross reacted with seasonal H1N1 and H3N2 influenza viruses.

Original language	English
Pages (from-to)	388-393
Number of pages	6
Journal	Journal of Infection
Volume	62
Issue number	5
DOIs	https://doi.org/10.1016/j.jinf.2011.03.002
Publication status	Published - May 2011

Keywords

Antibody response
Cross reactive antibody
Haemagglutination inhibition
Influenza A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jinf.2011.03.002

Cite this

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title = "Serological responses following influenza A H1N1 2009 infection in adults",

abstract = "Objective: The aim of this study was to determine the humoral immune response to influenza A H1N1 2009 and cross reactivity against seasonal H1N1 and H3N2 strains. Methods: Baseline and convalescent sera from 88 subjects with confirmed H1N1 2009 were screened for serological responses by HAI assay. Results: Protective antibody titres to H1N1 2009 were present in 87% post-infection, but varied with age, sex and pregnancy. Some cross reactivity with seasonal influenza strains was observed. Conclusions: Females and pregnant subjects had an attenuated immune response to H1N1 2009 in comparison to the rest of the study population. Antibodies from the serum of H1N1 2009 infected subjects cross reacted with seasonal H1N1 and H3N2 influenza viruses.",

keywords = "Antibody response, Cross reactive antibody, Haemagglutination inhibition, Influenza A",

author = "Sophia Tan and David Gordon and Y. Honda-Okubo and Nikolai Petrovsky and Peter Phillips and Sandra Huddleston and Tania Sadlon",

year = "2011",

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doi = "10.1016/j.jinf.2011.03.002",

language = "English",

volume = "62",

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TY - JOUR

T1 - Serological responses following influenza A H1N1 2009 infection in adults

AU - Tan, Sophia

AU - Gordon, David

AU - Honda-Okubo, Y.

AU - Petrovsky, Nikolai

AU - Phillips, Peter

AU - Huddleston, Sandra

AU - Sadlon, Tania

PY - 2011/5

Y1 - 2011/5

N2 - Objective: The aim of this study was to determine the humoral immune response to influenza A H1N1 2009 and cross reactivity against seasonal H1N1 and H3N2 strains. Methods: Baseline and convalescent sera from 88 subjects with confirmed H1N1 2009 were screened for serological responses by HAI assay. Results: Protective antibody titres to H1N1 2009 were present in 87% post-infection, but varied with age, sex and pregnancy. Some cross reactivity with seasonal influenza strains was observed. Conclusions: Females and pregnant subjects had an attenuated immune response to H1N1 2009 in comparison to the rest of the study population. Antibodies from the serum of H1N1 2009 infected subjects cross reacted with seasonal H1N1 and H3N2 influenza viruses.

AB - Objective: The aim of this study was to determine the humoral immune response to influenza A H1N1 2009 and cross reactivity against seasonal H1N1 and H3N2 strains. Methods: Baseline and convalescent sera from 88 subjects with confirmed H1N1 2009 were screened for serological responses by HAI assay. Results: Protective antibody titres to H1N1 2009 were present in 87% post-infection, but varied with age, sex and pregnancy. Some cross reactivity with seasonal influenza strains was observed. Conclusions: Females and pregnant subjects had an attenuated immune response to H1N1 2009 in comparison to the rest of the study population. Antibodies from the serum of H1N1 2009 infected subjects cross reacted with seasonal H1N1 and H3N2 influenza viruses.

KW - Antibody response

KW - Cross reactive antibody

KW - Haemagglutination inhibition

KW - Influenza A

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U2 - 10.1016/j.jinf.2011.03.002

DO - 10.1016/j.jinf.2011.03.002

M3 - Article

SN - 0163-4453

VL - 62

SP - 388

EP - 393

JO - Journal of Infection

JF - Journal of Infection

IS - 5

ER -

Serological responses following influenza A H1N1 2009 infection in adults

Abstract

Keywords

UN SDGs

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