TY - JOUR
T1 - Serum surfactant protein-A levels in patients with acute cardiogenic pulmonary edema and adult respiratory distress syndrome
AU - Doyle, Ian R.
AU - Nicholas, Terence E.
AU - Bersten, Andrew D.
PY - 1995/7
Y1 - 1995/7
N2 - Detection of alveolo-capillary damage has important implications for treatment modalities in ventilated patients. Although surfactant protein-A (SP-A) is normally only found in appreciable amounts in the lung, we describe significantly elevated concentrations in the sere of patients with acute cardiogenic pulmonary edema (median, 250 ng/ml; range, 180 to 364; n = 10) and in those with the adult respiratory distress syndrome (ARDS) (median, 378 ng/ml; range, 215 to 1,378; n = 15) relative to healthy control subjects (median, 175 ng/ml; range, 123 to 248; n = 15) and ventilated patients with no cardiorespiratory disease (median, 169 ng/ml; range, 126 to 253; n = 6) (p < 0.01, in all cases). Serum SP-A was inversely related to blood oxygenation and to static respiratory system compliance both at the time of the patient's entry into the study (p < 0.005, r(s) = -0.51, n = 31; p < 0.001, r(s) = 0.82, n = 17; respectively) and during the course of admission (p < 0.001, r(s) = -0.34, n = 168; p < 0.001, r(s) = -0.50, n = 111; respectively). In addition, we describe in detail three cases of ARDS where lung function either improved, remained static, or deteriorated. We conclude that serum SP- A is an acute indicator of lung function and alveolocapillary membrane injury.
AB - Detection of alveolo-capillary damage has important implications for treatment modalities in ventilated patients. Although surfactant protein-A (SP-A) is normally only found in appreciable amounts in the lung, we describe significantly elevated concentrations in the sere of patients with acute cardiogenic pulmonary edema (median, 250 ng/ml; range, 180 to 364; n = 10) and in those with the adult respiratory distress syndrome (ARDS) (median, 378 ng/ml; range, 215 to 1,378; n = 15) relative to healthy control subjects (median, 175 ng/ml; range, 123 to 248; n = 15) and ventilated patients with no cardiorespiratory disease (median, 169 ng/ml; range, 126 to 253; n = 6) (p < 0.01, in all cases). Serum SP-A was inversely related to blood oxygenation and to static respiratory system compliance both at the time of the patient's entry into the study (p < 0.005, r(s) = -0.51, n = 31; p < 0.001, r(s) = 0.82, n = 17; respectively) and during the course of admission (p < 0.001, r(s) = -0.34, n = 168; p < 0.001, r(s) = -0.50, n = 111; respectively). In addition, we describe in detail three cases of ARDS where lung function either improved, remained static, or deteriorated. We conclude that serum SP- A is an acute indicator of lung function and alveolocapillary membrane injury.
UR - http://www.scopus.com/inward/record.url?scp=0029111616&partnerID=8YFLogxK
U2 - 10.1164/ajrccm.152.1.7599839
DO - 10.1164/ajrccm.152.1.7599839
M3 - Article
C2 - 7599839
AN - SCOPUS:0029111616
VL - 152
SP - 307
EP - 317
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 1
ER -