Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation

Sumedh Jayanti; Nadim A. Beruni; Juanita Noeline Chui; Danny Deng; Amy Liang; Anita Chong; Jonathan C. Craig; Bethany Foster; Martin Howell; Siah Kim; Ruth Sapir-Pichhadze; Roslyn B. Mannon; Nicole Scholes-Robertson; Alexandra Strauss; Allison Tong; Lori West; Tess E. Cooper; Germaine Wong

doi:10.1002/14651858.CD014966

Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation

Sumedh Jayanti, Nadim A. Beruni, Juanita Noeline Chui, Danny Deng, Amy Liang, Anita Chong, Jonathan C. Craig, Bethany Foster, Martin Howell, Siah Kim, Ruth Sapir-Pichhadze, Roslyn B. Mannon, Nicole Scholes-Robertson, Alexandra Strauss, Allison Tong, Lori West, Tess E. Cooper, Germaine Wong

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. To evaluate the prognostic effect of the recipient's (i) sex and gender separately (ii) gender as an independent predictor of patient-relevant outcomes at any time period following kidney or SPK transplantation () and explore sources of heterogeneity. We aim to evaluate this prognostic effect by (a) clearly defining the relationship between recipient sex/gender and post-transplantation outcomes, which would involve identifying reasons for variations between sexes and genders, and then (b) quantifying the magnitude of this relationship. 1 PICOTS summary of "Sex and gender as predictors for allograft and patient relevant outcomes after kidney transplantation" (Table presented.) "Criteria for Prognostic Reviews: Population, Index (prognostic factor), Comparator, Outcomes, Timing, Setting (PICOTS)" (Moons 2014). Investigation of sources of heterogeneity between studies Sources of heterogeneity may exist between studies that can have an impact on outcomes. We will explore potential sources, which may include patient age, self-reported ethnicity, country of transplantation, transplant era, living versus deceased donor transplantation, definitions and units used for outcomes, quality of the study, and the indication for kidney transplantation.

Original language	English
Article number	CD014966
Number of pages	16
Journal	Cochrane Database of Systematic Reviews
Volume	2022
Issue number	2
DOIs	https://doi.org/10.1002/14651858.CD014966
Publication status	Published - 28 Feb 2022

Bibliographical note

Funding Information:
We wish to acknowledge Ruth Mitchell, Information Specialist of the Cochrane Kidney and Transplant Group for developing the search strategies for this protocol. We wish to acknowledge the Cochrane Prognostic Methods Group for their invaluable input to the methodology in the initial planning stages of this protocol. The authors are grateful to the following peer reviewers for their time and comments: Dr Ashley Irish (Nephrologist and Transplant Physician, Fiona Stanley Hospital Murdoch WA, Australia), Ellon McGregor (Glasgow Renal and Transplant Unit, Glasgow, UK), and Nina KreuzBerger (Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany). Editorial contributions Sign-off Editor (final editorial decision): Giovanni Strippoli (Cochrane Kidney and Transplant) Managing Editor (selected peer reviewers, collated peer-reviewer comments, provided editorial guidance to authors, edited the article): Narelle Willis (Cochrane Kidney and Transplant) Sign-off Editor (final editorial decision): Giovanni Strippoli (Cochrane Kidney and Transplant) Managing Editor (selected peer reviewers, collated peer-reviewer comments, provided editorial guidance to authors, edited the article): Narelle Willis (Cochrane Kidney and Transplant)

Publisher Copyright:
Copyright © 2022 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Keywords

Sex
Gender
Kidney Transplantation

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Jayanti, S., Beruni, N. A., Chui, J. N., Deng, D., Liang, A., Chong, A., Craig, J. C., Foster, B., Howell, M., Kim, S., Sapir-Pichhadze, R., Mannon, R. B., Scholes-Robertson, N., Strauss, A., Tong, A., West, L., Cooper, T. E., & Wong, G. (2022). Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation. Cochrane Database of Systematic Reviews, 2022(2), Article CD014966. https://doi.org/10.1002/14651858.CD014966

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abstract = "Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. To evaluate the prognostic effect of the recipient's (i) sex and gender separately (ii) gender as an independent predictor of patient-relevant outcomes at any time period following kidney or SPK transplantation () and explore sources of heterogeneity. We aim to evaluate this prognostic effect by (a) clearly defining the relationship between recipient sex/gender and post-transplantation outcomes, which would involve identifying reasons for variations between sexes and genders, and then (b) quantifying the magnitude of this relationship. 1 PICOTS summary of {"}Sex and gender as predictors for allograft and patient relevant outcomes after kidney transplantation{"} (Table presented.) {"}Criteria for Prognostic Reviews: Population, Index (prognostic factor), Comparator, Outcomes, Timing, Setting (PICOTS){"} (Moons 2014). Investigation of sources of heterogeneity between studies Sources of heterogeneity may exist between studies that can have an impact on outcomes. We will explore potential sources, which may include patient age, self-reported ethnicity, country of transplantation, transplant era, living versus deceased donor transplantation, definitions and units used for outcomes, quality of the study, and the indication for kidney transplantation.",

keywords = "Sex, Gender, Kidney Transplantation",

author = "Sumedh Jayanti and Beruni, {Nadim A.} and Chui, {Juanita Noeline} and Danny Deng and Amy Liang and Anita Chong and Craig, {Jonathan C.} and Bethany Foster and Martin Howell and Siah Kim and Ruth Sapir-Pichhadze and Mannon, {Roslyn B.} and Nicole Scholes-Robertson and Alexandra Strauss and Allison Tong and Lori West and Cooper, {Tess E.} and Germaine Wong",

note = "Funding Information: We wish to acknowledge Ruth Mitchell, Information Specialist of the Cochrane Kidney and Transplant Group for developing the search strategies for this protocol. We wish to acknowledge the Cochrane Prognostic Methods Group for their invaluable input to the methodology in the initial planning stages of this protocol. The authors are grateful to the following peer reviewers for their time and comments: Dr Ashley Irish (Nephrologist and Transplant Physician, Fiona Stanley Hospital Murdoch WA, Australia), Ellon McGregor (Glasgow Renal and Transplant Unit, Glasgow, UK), and Nina KreuzBerger (Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany). Editorial contributions Sign-off Editor (final editorial decision): Giovanni Strippoli (Cochrane Kidney and Transplant) Managing Editor (selected peer reviewers, collated peer-reviewer comments, provided editorial guidance to authors, edited the article): Narelle Willis (Cochrane Kidney and Transplant) Sign-off Editor (final editorial decision): Giovanni Strippoli (Cochrane Kidney and Transplant) Managing Editor (selected peer reviewers, collated peer-reviewer comments, provided editorial guidance to authors, edited the article): Narelle Willis (Cochrane Kidney and Transplant) Publisher Copyright: Copyright {\textcopyright} 2022 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.",

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doi = "10.1002/14651858.CD014966",

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Jayanti, S, Beruni, NA, Chui, JN, Deng, D, Liang, A, Chong, A, Craig, JC, Foster, B, Howell, M, Kim, S, Sapir-Pichhadze, R, Mannon, RB, Scholes-Robertson, N, Strauss, A, Tong, A, West, L, Cooper, TE & Wong, G 2022, 'Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation', Cochrane Database of Systematic Reviews, vol. 2022, no. 2, CD014966. https://doi.org/10.1002/14651858.CD014966

TY - JOUR

T1 - Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation

AU - Jayanti, Sumedh

AU - Beruni, Nadim A.

AU - Chui, Juanita Noeline

AU - Deng, Danny

AU - Liang, Amy

AU - Chong, Anita

AU - Craig, Jonathan C.

AU - Foster, Bethany

AU - Howell, Martin

AU - Kim, Siah

AU - Sapir-Pichhadze, Ruth

AU - Mannon, Roslyn B.

AU - Scholes-Robertson, Nicole

AU - Strauss, Alexandra

AU - Tong, Allison

AU - West, Lori

AU - Cooper, Tess E.

AU - Wong, Germaine

N1 - Funding Information: We wish to acknowledge Ruth Mitchell, Information Specialist of the Cochrane Kidney and Transplant Group for developing the search strategies for this protocol. We wish to acknowledge the Cochrane Prognostic Methods Group for their invaluable input to the methodology in the initial planning stages of this protocol. The authors are grateful to the following peer reviewers for their time and comments: Dr Ashley Irish (Nephrologist and Transplant Physician, Fiona Stanley Hospital Murdoch WA, Australia), Ellon McGregor (Glasgow Renal and Transplant Unit, Glasgow, UK), and Nina KreuzBerger (Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany). Editorial contributions Sign-off Editor (final editorial decision): Giovanni Strippoli (Cochrane Kidney and Transplant) Managing Editor (selected peer reviewers, collated peer-reviewer comments, provided editorial guidance to authors, edited the article): Narelle Willis (Cochrane Kidney and Transplant) Sign-off Editor (final editorial decision): Giovanni Strippoli (Cochrane Kidney and Transplant) Managing Editor (selected peer reviewers, collated peer-reviewer comments, provided editorial guidance to authors, edited the article): Narelle Willis (Cochrane Kidney and Transplant) Publisher Copyright: Copyright © 2022 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

PY - 2022/2/28

Y1 - 2022/2/28

N2 - Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. To evaluate the prognostic effect of the recipient's (i) sex and gender separately (ii) gender as an independent predictor of patient-relevant outcomes at any time period following kidney or SPK transplantation () and explore sources of heterogeneity. We aim to evaluate this prognostic effect by (a) clearly defining the relationship between recipient sex/gender and post-transplantation outcomes, which would involve identifying reasons for variations between sexes and genders, and then (b) quantifying the magnitude of this relationship. 1 PICOTS summary of "Sex and gender as predictors for allograft and patient relevant outcomes after kidney transplantation" (Table presented.) "Criteria for Prognostic Reviews: Population, Index (prognostic factor), Comparator, Outcomes, Timing, Setting (PICOTS)" (Moons 2014). Investigation of sources of heterogeneity between studies Sources of heterogeneity may exist between studies that can have an impact on outcomes. We will explore potential sources, which may include patient age, self-reported ethnicity, country of transplantation, transplant era, living versus deceased donor transplantation, definitions and units used for outcomes, quality of the study, and the indication for kidney transplantation.

AB - Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. To evaluate the prognostic effect of the recipient's (i) sex and gender separately (ii) gender as an independent predictor of patient-relevant outcomes at any time period following kidney or SPK transplantation () and explore sources of heterogeneity. We aim to evaluate this prognostic effect by (a) clearly defining the relationship between recipient sex/gender and post-transplantation outcomes, which would involve identifying reasons for variations between sexes and genders, and then (b) quantifying the magnitude of this relationship. 1 PICOTS summary of "Sex and gender as predictors for allograft and patient relevant outcomes after kidney transplantation" (Table presented.) "Criteria for Prognostic Reviews: Population, Index (prognostic factor), Comparator, Outcomes, Timing, Setting (PICOTS)" (Moons 2014). Investigation of sources of heterogeneity between studies Sources of heterogeneity may exist between studies that can have an impact on outcomes. We will explore potential sources, which may include patient age, self-reported ethnicity, country of transplantation, transplant era, living versus deceased donor transplantation, definitions and units used for outcomes, quality of the study, and the indication for kidney transplantation.

KW - Sex

KW - Gender

KW - Kidney Transplantation

UR - http://www.scopus.com/inward/record.url?scp=85125452795&partnerID=8YFLogxK

U2 - 10.1002/14651858.CD014966

DO - 10.1002/14651858.CD014966

M3 - Review article

AN - SCOPUS:85125452795

SN - 1465-1858

VL - 2022

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

IS - 2

M1 - CD014966

ER -

Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation

Abstract

Bibliographical note

Keywords

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