Sex hormone binding globulin, but not testosterone, is associated with the metabolic syndrome in overweight and obese women with polycystic ovary syndrome

Lisa Moran, Helena Teede, Manila Noakes, Peter Clifton, Robert Norman, Gary Wittert

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Background: Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and an increased risk of Type 2 diabetes and cardiovascular disease. Decreased SHBG and elevated testosterone are associated with metabolic syndrome and glucose intolerance in women. Aim: The aim of this study was to assess the relationship between SHBG and testosterone and metabolic syndrome and glucose intolerance in PCOS. Material/subjects and methods: Cross-sectional study in overweight and obese premenopausal non-diabetic women with PCOS (no.=178: no.=55 metabolic syndrome, no.=16 glucose intolerance). Data were analyzed by multiple regression with metabolic syndrome, oral glucose tolerance test (OGTT) glucose or SHBG as dependent variables and reproductive hormones, insulin resistance, glucose tolerance, lipids or C-reactive protein as independent variables. Results: Metabolic syndrome was independently associated with body mass index [odds ratio (OR) 1.084 95% confidence interval (CI) 1.034-1.170, p =0.015] and SHBG (OR 0.961 95% CI 0.932-0.995, p=0.018). Glucose tolerance was independently associated with OGTT insulin (β=0.418, p < 0.001), age (β=0.154, p =0.033) and PRL (β=-0.210, p =0.002). SHBG was independently associated with OGTT insulin (β=-0.216, p=0.014) and PCOS diagnostic criteria (β=0.197, p=0.010). Conclusions: SHBG, but not testosterone, is independently associated with metabolic syndrome in overweight women with PCOS and is associated with insulin resistance and PCOS diagnostic criteria.

    Original languageEnglish
    Pages (from-to)1004-1010
    Number of pages7
    JournalJournal of Endocrinological Investigation
    Volume36
    Issue number11
    DOIs
    Publication statusPublished - Dec 2013

    Keywords

    • Hyperandrogenism
    • Metabolic syndrome
    • Polycystic ovary syndrome
    • Sex hormone binding globulin
    • Type 2 diabetes mellitus

    Fingerprint Dive into the research topics of 'Sex hormone binding globulin, but not testosterone, is associated with the metabolic syndrome in overweight and obese women with polycystic ovary syndrome'. Together they form a unique fingerprint.

    Cite this