Abstract
Bronchiolitis is characterized histologically by epithelial necrosis and peribronchial infiltration of leukocytes, with a high percentage of neutrophils in the airways. We investigated the expression of adhesion molecules (CD11a, CD11b, CD18, CD31, CD54, and CD62L) on neutrophils from nasopharyngeal aspirates (NPAs) and peripheral blood (PB) of infants with respiratory syncytial virus (RSV)-induced bronchiolitis. The expression of CD31 and CD62L on neutrophils from NPAs is decreased and the expression of CD11b, CD18, and CD54 on neutrophils from NPAs is increased compared with cells from PB of RSV-infected infants. The expression of CD18 and CD54 on neutrophils from PB of RSV-infected infants is also increased compared with cells from PB of control infants. Shedding of CD31 and CD62L on neutrophils in RSV infection may contribute to the neutrophil emigration from blood to airways; the upregulation of Mac-1 (CD11b/CD18) and CD54 on neutrophils may help explain the high percentage of neutrophils in the airways of RSV bronchiolitis; and the upregulation of Mac-1 may be involved in the increased neutrophil-airway epithelial adhesion in RSV infection.
| Original language | English |
|---|---|
| Pages (from-to) | L983-L989 |
| Number of pages | 7 |
| Journal | American Journal of Physiology - Lung Cellular and Molecular Physiology |
| Volume | 275 |
| Issue number | 5 |
| Publication status | Published - Nov 1998 |
| Externally published | Yes |
Keywords
- Adhesion molecule expression
- Airway
- Emigration
- Intercellular adhesion molecule-1
- Platelet endothelial cell adhesion molecule-1
- Polymorphonuclear leukocyte
- Respiratory syncytial virus
- Viral infection