Silica Nanopills for Targeted Anticancer Drug Delivery

María Alba; Bahman Delalat; Pilar Formentín; Mary-Louise Rogers; Lluís Marsa; Nicholas Nicholas

doi:10.1002/smll.201402930

Silica Nanopills for Targeted Anticancer Drug Delivery

María Alba, Bahman Delalat, Pilar Formentín, Mary-Louise Rogers, Lluís Marsa, Nicholas Nicholas

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Multifunctional SiO₂ microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.

Original language	English
Pages (from-to)	4626-4631
Number of pages	6
Journal	Small
Volume	11
Issue number	36
DOIs	https://doi.org/10.1002/smll.201402930
Publication status	Published - 1 Sept 2015

Keywords

antibodies
cancer therapy
drug delivery
microtubes
porous silicon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smll.201402930

Cite this

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title = "Silica Nanopills for Targeted Anticancer Drug Delivery",

abstract = "Multifunctional SiO2 microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.",

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author = "Mar{\'i}a Alba and Bahman Delalat and Pilar Forment{\'i}n and Mary-Louise Rogers and Llu{\'i}s Marsa and Nicholas Nicholas",

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T1 - Silica Nanopills for Targeted Anticancer Drug Delivery

AU - Alba, María

AU - Delalat, Bahman

AU - Formentín, Pilar

AU - Rogers, Mary-Louise

AU - Marsa, Lluís

AU - Nicholas, Nicholas

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Multifunctional SiO2 microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.

AB - Multifunctional SiO2 microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.

KW - antibodies

KW - cancer therapy

KW - drug delivery

KW - microtubes

KW - porous silicon

UR - http://www.scopus.com/inward/record.url?scp=84942369437&partnerID=8YFLogxK

U2 - 10.1002/smll.201402930

DO - 10.1002/smll.201402930

M3 - Article

SN - 1613-6829

VL - 11

SP - 4626

EP - 4631

JO - Small

JF - Small

IS - 36

ER -

Silica Nanopills for Targeted Anticancer Drug Delivery

Abstract

Keywords

UN SDGs

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