Simultaneous gallbladder and bile duct cancers: revisiting the pathological possibilities

P. J. Shukla, S. G. Barreto, S. V. Shrikhande, M. R. Ramadwar, K. K. Deodhar, Shaesta Mehta, P. Patil, K. M. Mohandas

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The pathogenesis of gallbladder cancer presenting synchronously with malignancy of the bile duct has not been clearly understood. The possible causes for the simultaneous presence of these tumors could be due to local spread, metastases, de novo multifocal origin, or as part of a field change in the extrahepatic biliary apparatus. In this article, we discuss the cases of four patients with simultaneous gallbladder and bile duct malignancies and analyze their individual pathologies to provide an explanation into the mechanisms that may play a role in such conditions.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
Issue number1
Publication statusPublished - Feb 2008
Externally publishedYes


  • Cancer
  • Cholangiocarcinoma
  • Field cancerization
  • Gall bladder
  • Synchronous


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