Sister chromatid exchange in aplastic anemia

Ram Seshadri; Elizabeth Baker; Peter Leonard; Grant Sutherland; Alexander A. Morley

doi:10.1016/0165-4608(81)90059-5

Sister chromatid exchange in aplastic anemia

Ram Seshadri, Elizabeth Baker, Peter Leonard, Grant Sutherland, Alexander A. Morley

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Abstract

The incidence of sister chromatid exchanges (SCE) in the lymphocytes of patients with aplastic anemia (AA) was determined before and after exposure to mitomycin C (MMC). The "baseline" SCE rate was significantly higher in AA, but MMC-induced SCE rate was not different compared to controls. It is suggested that some patients with AA may have an underlying DNA damage.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(81)90059-5
Publication status	Published - Jan 1981

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title = "Sister chromatid exchange in aplastic anemia",

abstract = "The incidence of sister chromatid exchanges (SCE) in the lymphocytes of patients with aplastic anemia (AA) was determined before and after exposure to mitomycin C (MMC). The {"}baseline{"} SCE rate was significantly higher in AA, but MMC-induced SCE rate was not different compared to controls. It is suggested that some patients with AA may have an underlying DNA damage.",

author = "Ram Seshadri and Elizabeth Baker and Peter Leonard and Grant Sutherland and Morley, {Alexander A.}",

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AU - Leonard, Peter

AU - Sutherland, Grant

AU - Morley, Alexander A.

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N2 - The incidence of sister chromatid exchanges (SCE) in the lymphocytes of patients with aplastic anemia (AA) was determined before and after exposure to mitomycin C (MMC). The "baseline" SCE rate was significantly higher in AA, but MMC-induced SCE rate was not different compared to controls. It is suggested that some patients with AA may have an underlying DNA damage.

AB - The incidence of sister chromatid exchanges (SCE) in the lymphocytes of patients with aplastic anemia (AA) was determined before and after exposure to mitomycin C (MMC). The "baseline" SCE rate was significantly higher in AA, but MMC-induced SCE rate was not different compared to controls. It is suggested that some patients with AA may have an underlying DNA damage.

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AN - SCOPUS:0019459705

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VL - 3

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Sister chromatid exchange in aplastic anemia

Abstract

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