Sister chromatid exchange in aplastic anemia

Ram Seshadri, Elizabeth Baker, Peter Leonard, Grant Sutherland, Alexander A. Morley

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    The incidence of sister chromatid exchanges (SCE) in the lymphocytes of patients with aplastic anemia (AA) was determined before and after exposure to mitomycin C (MMC). The "baseline" SCE rate was significantly higher in AA, but MMC-induced SCE rate was not different compared to controls. It is suggested that some patients with AA may have an underlying DNA damage.

    Original languageEnglish
    Pages (from-to)81-84
    Number of pages4
    JournalCancer Genetics and Cytogenetics
    Issue number1
    Publication statusPublished - Jan 1981


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