Sleep Apnea Phenotyping: Implications for Dental Sleep Medicine

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    New knowledge of obstructive sleep apnea (OSA) pathophysiology has highlighted the heterogeneity of this common chronic health
    condition. Recent advances in OSA ‘phenotyping’ concepts have provided a novel framework in which to understand OSA
    pathophysiology on an individual patient basis. This has also provided new potential precision medicine strategies to optimize efficacy
    and success rates with current OSA treatments including mandibular advancement therapy.
    This review summarizes how different ‘phenotypes’ contribute to OSA pathophysiology and highlights the potential mechanisms by
    which mandibular advancement splints alter upper airway physiology according to an OSA phenotyping framework. In addition, it
    explains how understanding these phenotypes can facilitate novel and improved approaches to therapy, with a focus on phenotyping to
    improve mandibular advancement splint treatment prediction and efficacy. The potential to translate phenotyping concepts into the
    clinical setting is also discussed.
    Original languageEnglish
    Number of pages12
    JournalJournal of Dental Sleep Medicine
    Volume6
    Issue number2
    DOIs
    Publication statusPublished - 2019

    Keywords

    • Sleep-disordered breathing
    • Obstructive sleep apnea
    • phenotyping
    • airway pressure

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