Abstract
New knowledge of obstructive sleep apnea (OSA) pathophysiology has highlighted the heterogeneity of this common chronic health
condition. Recent advances in OSA ‘phenotyping’ concepts have provided a novel framework in which to understand OSA
pathophysiology on an individual patient basis. This has also provided new potential precision medicine strategies to optimize efficacy
and success rates with current OSA treatments including mandibular advancement therapy.
This review summarizes how different ‘phenotypes’ contribute to OSA pathophysiology and highlights the potential mechanisms by
which mandibular advancement splints alter upper airway physiology according to an OSA phenotyping framework. In addition, it
explains how understanding these phenotypes can facilitate novel and improved approaches to therapy, with a focus on phenotyping to
improve mandibular advancement splint treatment prediction and efficacy. The potential to translate phenotyping concepts into the
clinical setting is also discussed.
condition. Recent advances in OSA ‘phenotyping’ concepts have provided a novel framework in which to understand OSA
pathophysiology on an individual patient basis. This has also provided new potential precision medicine strategies to optimize efficacy
and success rates with current OSA treatments including mandibular advancement therapy.
This review summarizes how different ‘phenotypes’ contribute to OSA pathophysiology and highlights the potential mechanisms by
which mandibular advancement splints alter upper airway physiology according to an OSA phenotyping framework. In addition, it
explains how understanding these phenotypes can facilitate novel and improved approaches to therapy, with a focus on phenotyping to
improve mandibular advancement splint treatment prediction and efficacy. The potential to translate phenotyping concepts into the
clinical setting is also discussed.
| Original language | English |
|---|---|
| Number of pages | 12 |
| Journal | Journal of Dental Sleep Medicine |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Sleep-disordered breathing
- Obstructive sleep apnea
- phenotyping
- airway pressure