Sleep EEG microstructure is associated with neurobehavioural impairment after extended wakefulness in obstructive sleep apnea

Anna E. Mullins, Jong W. Kim, Keith K.H. Wong, Delwyn J. Bartlett, Andrew Vakulin, Derk Jan Dijk, Nathaniel S. Marshall, Ronald R. Grunstein, Angela L. D’Rozario

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: Using quantitative EEG (qEEG) analysis, we investigated sleep EEG microstructure as correlates of neurobehavioural performance after 24 h of extended wakefulness in untreated OSA. Methods: Eight male OSA patients underwent overnight polysomnography (PSG) at baseline followed by 40 h awake with repeated performance testing (psychomotor vigilance task [PVT] and AusEd driving simulator). EEG slowing during REM and spindle density during NREM sleep were calculated using power spectral analysis and a spindle detection algorithm at frontal and central electrode sites. Correlations between sleep EEG microstructure measures and performance after 24-h awake were assessed. Results: Greater EEG slowing during REM sleep was associated with slower PVT reaction times (rho = − 0.79, p = 0.02), more PVT lapses (rho = 0.87, p = 0.005) and more AusEd crashes (rho = 0.73, p = 0.04). Decreased spindle density in NREM sleep was also associated with slower PVT reaction times (rho = 0.89, p = 0.007). Traditional PSG measures of disease severity were not consistent correlates of neurobehavioural performance in OSA. Conclusions: Sleep EEG microstructure measures recorded during routine PSG are associated with impaired vigilance in OSA patients after sleep deprivation. Significance: Quantitative brain oscillatory (or EEG)–based measures of sleep may better reflect the deleterious effects of untreated OSA than traditional PSG metrics in at-risk individuals. Trial Registration ACTRN12606000066583.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalSleep and Breathing
Volume25
Issue number1
Early online date9 Aug 2020
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Cognition
  • Quantitative EEG
  • Sleep deprivation
  • Sleep disordered breathing
  • Sleep spindles
  • Spectral analysis

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