Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources

K. K.W. Siu, S. Sidhu, G. Falzon, S. Nazaretian, S. A. Hart, J. G. Fox, R. A. Lewis

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationDiagnostic Imaging
EditorsProf. Dr. Olaf Dossel, Prof. Dr. Wolfgang C. Schlegel
Pages607-610
Number of pages4
ISBN (Electronic)9783642038792
DOIs
Publication statusPublished - 2009
Externally publishedYes
EventWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Publication series

NameIFMBE Proceedings
Number2
Volume25
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
CountryGermany
CityMunich
Period7/09/0912/09/09

Keywords

  • Breast cancer
  • Extra-cellular matrix
  • X-ray scattering

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