Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources

K. K.W. Siu; S. Sidhu; G. Falzon; S. Nazaretian; S. A. Hart; J. G. Fox; R. A. Lewis

doi:10.1007/978-3-642-03879-2_170

Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources

K. K.W. Siu
, S. Sidhu
, G. Falzon
, S. Nazaretian
, S. A. Hart
, J. G. Fox
, R. A. Lewis

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering
Subtitle of host publication	Diagnostic Imaging
Editors	Prof. Dr. Olaf Dossel, Prof. Dr. Wolfgang C. Schlegel
Pages	607-610
Number of pages	4
ISBN (Electronic)	9783642038792
DOIs	https://doi.org/10.1007/978-3-642-03879-2_170
Publication status	Published - 2009
Externally published	Yes
Event	World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich, Germany Duration: 7 Sept 2009 → 12 Sept 2009

Publication series

Name	IFMBE Proceedings
Number	2
Volume	25
ISSN (Print)	1680-0737

Conference

Conference	World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
Country/Territory	Germany
City	Munich
Period	7/09/09 → 12/09/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Extra-cellular matrix
X-ray scattering

Access to Document

10.1007/978-3-642-03879-2_170Licence: In Copyright

Cite this

Siu, K. K. W., Sidhu, S., Falzon, G., Nazaretian, S., Hart, S. A., Fox, J. G., & Lewis, R. A. (2009). Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. In P. D. O. Dossel, & P. D. W. C. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging (pp. 607-610). (IFMBE Proceedings; Vol. 25, No. 2). https://doi.org/10.1007/978-3-642-03879-2_170

@inproceedings{f884802eb99443588c993533d34db892,

title = "Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources",

abstract = "Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.",

keywords = "Breast cancer, Extra-cellular matrix, X-ray scattering",

author = "Siu, \{K. K.W.\} and S. Sidhu and G. Falzon and S. Nazaretian and Hart, \{S. A.\} and Fox, \{J. G.\} and Lewis, \{R. A.\}",

year = "2009",

doi = "10.1007/978-3-642-03879-2\_170",

language = "English",

isbn = "9783642038785",

series = "IFMBE Proceedings",

number = "2",

pages = "607--610",

editor = "Dossel, \{Prof. Dr. Olaf\} and Schlegel, \{Prof. Dr. Wolfgang C.\}",

booktitle = "World Congress on Medical Physics and Biomedical Engineering",

note = "World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging ; Conference date: 07-09-2009 Through 12-09-2009",

}

Siu, KKW, Sidhu, S, Falzon, G, Nazaretian, S, Hart, SA, Fox, JG & Lewis, RA 2009, Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. in PDO Dossel & PDWC Schlegel (eds), World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. IFMBE Proceedings, no. 2, vol. 25, pp. 607-610, World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging, Munich, Germany, 7/09/09. https://doi.org/10.1007/978-3-642-03879-2_170

Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. / Siu, K. K.W.; Sidhu, S.; Falzon, G. et al.
World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. ed. / Prof. Dr. Olaf Dossel; Prof. Dr. Wolfgang C. Schlegel. 2009. p. 607-610 (IFMBE Proceedings; Vol. 25, No. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Small angle X-ray scattering signatures for breast cancer detection

T2 - World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging

AU - Siu, K. K.W.

AU - Sidhu, S.

AU - Falzon, G.

AU - Nazaretian, S.

AU - Hart, S. A.

AU - Fox, J. G.

AU - Lewis, R. A.

PY - 2009

Y1 - 2009

N2 - Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

AB - Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

KW - Breast cancer

KW - Extra-cellular matrix

KW - X-ray scattering

UR - https://www.scopus.com/pages/publications/77950897680

U2 - 10.1007/978-3-642-03879-2_170

DO - 10.1007/978-3-642-03879-2_170

M3 - Conference contribution

AN - SCOPUS:77950897680

SN - 9783642038785

T3 - IFMBE Proceedings

SP - 607

EP - 610

BT - World Congress on Medical Physics and Biomedical Engineering

A2 - Dossel, Prof. Dr. Olaf

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ER -

Siu KKW, Sidhu S, Falzon G, Nazaretian S, Hart SA, Fox JG et al. Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources. In Dossel PDO, Schlegel PDWC, editors, World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging. 2009. p. 607-610. (IFMBE Proceedings; 2). doi: 10.1007/978-3-642-03879-2_170

Small angle X-ray scattering signatures for breast cancer detection: Direct comparison of synchrotron and laboratory x-ray sources

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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