Small intestinal bacterial overgrowth (SIBO) as a potential cause of impaired spermatogenesis

Kelton Tremellen, Karma Pearce

Research output: Contribution to journalLetterpeer-review

10 Citations (Scopus)
22 Downloads (Pure)


We commend Ding and colleagues for their innovative work investigating how high-fat diet-induced changes to the gut microbiome can alter spermatogenesis.1 This link between the gut microbiome and testicular function had earlier been suggested by studies that reported the consumption of probiotic bacteria could improve spermatogenesis and testosterone production in both mice and men.2 3 Furthermore, we had earlier published the Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) theory that outlined the scientific evidence behind why obesity related change in the gut microbiome, and the associated increase in intestinal permeability with passage of gut bacterial endotoxin (metabolic endotoxaemia, ME) into the systemic circulation, may impair testicular function.
Original languageEnglish
Pages (from-to)2058-2059
Number of pages2
Early online date17 Feb 2020
Publication statusPublished - 7 Oct 2020

Bibliographical note

this is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:


  • endocrine hormones
  • endotoxin
  • epithelial permeability
  • small intestine


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