Smart surface-enhanced Raman scattering traceable drug delivery systems

Lei Liu, Youhong Tang, Sheng Dai, Freddy Kleitz, Shizhang Qiao

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    A novel smart nanoparticle-based system has been developed for tracking intracellular drug delivery through surface-enhanced Raman scattering (SERS). This new drug delivery system (DDS) shows targeted cytotoxicity towards cancer cells via pH-cleavable covalent carboxylic hydrazone links and the SERS tracing capability based on gold@silica nanocarriers. Doxorubicin, as a model anticancer drug, was employed to compare SERS with conventional fluorescence tracing approaches. It is evident that SERS demonstrates higher sensitivity and resolution, revealing intracellular details, as the strengths of the original Raman signals can be amplified by SERS. Importantly, non-destructive SERS will provide the designed DDS with great autonomy and potential to study the dynamic procedures of non-fluorescent drug delivery into living cells.

    Original languageEnglish
    Pages (from-to)12803-12811
    Number of pages9
    JournalNanoscale
    Volume8
    Issue number25
    DOIs
    Publication statusPublished - 2016

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