Smooth muscle cells are the site of neurokinin-1 receptor localization in the arterial supply of the rat sciatic nerve

Wolfgang Kummer, Ryuichi Shigemoto, Rainer Haberberger

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The occurrence and distribution of the preferred receptor for the neuropeptide, substance P (SP), the neurokinin-1 receptor (NK1R) was investigated in the vascular supply of the rat sciatic nerve. Messenger RNA for NK1R was demonstrated by RT-PCR in the epineurial layer where the majority of small arteries and arterioles feeding the endoneurial vasculature are located. Immunoreactivity to NK1R-protein was localized on the smooth muscle cells of these arterial vessels by means of immunofluorescence using a polyclonal NK1R antiserum. This muscular localization of NK1R explains the previously reported [Zochodne, D.W. and Ho, L.T., J. Physiol. 444 (1991) 615- 630] moderate vasoconstrictor rather than vasodilator effects of SP in this vascular bed.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalNeuroscience letters
Volume259
Issue number2
DOIs
Publication statusPublished - 8 Jan 1999
Externally publishedYes

Keywords

  • Artery
  • Immunohistochemistry
  • Peripheral nerve
  • Substance P
  • Substance P receptor
  • Tachykinin receptor
  • Vasa nervorum

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