Somatic mutation and aging

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    A key prediction of the somatic mutation theory of aging is that there is an invariant relationship between life span and the number of random mutations. A number of studies at a number of gene loci have shown that somatic mutations of a variety of types accumulate with age. Dietary restriction, which prolongs life span, results in slowed accumulation of HPRT mutants in mice. Conversely, senescence-accelerated mice, which have been bred to have a shortened life span, show accelerated accumulation of somatic mutations.

    Original languageEnglish
    Pages (from-to)20-22
    Number of pages3
    JournalAnnals of the New York Academy of Sciences
    Issue number1
    Publication statusPublished - 1998

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