TY - JOUR
T1 - Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer’s Disease
AU - Barthelson, Karissa
AU - Newman, Morgan
AU - Lardelli, Michael
PY - 2020/5/2
Y1 - 2020/5/2
N2 - Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer’s disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis.
AB - Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer’s disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis.
KW - Alzheimer's disease
KW - amyloid
KW - amyloid-beta protein precursor
KW - endocytosis
KW - endosomes
KW - protein transport
UR - http://www.scopus.com/inward/record.url?scp=85182724245&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1061006
UR - http://purl.org/au-research/grants/NHMRC/1045507
U2 - 10.3233/ADR-200177
DO - 10.3233/ADR-200177
M3 - Review article
AN - SCOPUS:85182724245
SN - 2542-4823
VL - 4
SP - 123
EP - 140
JO - Journal of Alzheimer's Disease Reports
JF - Journal of Alzheimer's Disease Reports
IS - 1
ER -
