Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer’s Disease

Karissa Barthelson, Morgan Newman, Michael Lardelli

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Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer’s disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis.
Original languageEnglish
Pages (from-to)123-140
Number of pages18
JournalJournal of Alzheimer's Disease Reports
Issue number1
Publication statusPublished - 2 May 2020
Externally publishedYes


  • Alzheimer’s disease
  • amyloid
  • amyloid-beta protein precursor
  • endocytosis
  • endosomes
  • protein transport


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