Spatial profiling of gene signatures in synovial tissue informs treatment strategy for Rheumatoid Arthritis: ACR Convergence 2025 October 24-29, 2025 Chicago, IL

Vincent Wong; Katie Lowe; Annabelle Small; Christopher Altmann; Susanna Proudman; Malcolm Smith; Wittaya Suwakulsiri; Ranjeny Thomas; Chung Hoow Kok; Mihir Wechalekar

doi:10.1002/art.43421

Spatial profiling of gene signatures in synovial tissue informs treatment strategy for Rheumatoid Arthritis: ACR Convergence 2025 October 24-29, 2025 Chicago, IL

Vincent Wong
, Katie Lowe
, Annabelle Small
, Christopher Altmann
, Susanna Proudman
, Malcolm Smith
, Wittaya Suwakulsiri
, Ranjeny Thomas
, Chung Hoow Kok
, Mihir Wechalekar

College of Medicine and Public Health

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Background/Purpose: Rheumatoid arthritis (RA) shows heterogeneous therapeutic responses that may reflect diversity within synovial tissue (ST). We aimed to identify gene signatures that predict Adalimumab response and provide an initial spatial transcriptomic validation of their cellular context.

Original language	English
Pages (from-to)	963-964
Number of pages	2
Journal	Arthritis & Rheumatology
Volume	77
Issue number	S9
DOIs	https://doi.org/10.1002/art.43421
Publication status	Published - Oct 2025
Event	American College of Rheumatology Convergence 2025 - Chicago, United States Duration: 24 Oct 2025 → 29 Oct 2025

Keywords

Spatial profiling
gene signatures
Rheumatoid Arthritis

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10.1002/art.43421Licence: In Copyright

https://acrabstracts.org/abstract/spatial-profiling-of-gene-signatures-in-synovial-tissue-informs-treatment-strategy-for-rheumatoid-arthritis/Licence: In Copyright

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Wong, V., Lowe, K., Small, A., Altmann, C., Proudman, S., Smith, M., Suwakulsiri, W., Thomas, R., Kok, C. H., & Wechalekar, M. (2025). Spatial profiling of gene signatures in synovial tissue informs treatment strategy for Rheumatoid Arthritis: ACR Convergence 2025 October 24-29, 2025 Chicago, IL. Arthritis & Rheumatology, 77(S9), 963-964. https://doi.org/10.1002/art.43421

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title = "Spatial profiling of gene signatures in synovial tissue informs treatment strategy for Rheumatoid Arthritis: ACR Convergence 2025 October 24-29, 2025 Chicago, IL",

abstract = "Background/Purpose: Rheumatoid arthritis (RA) shows heterogeneous therapeutic responses that may reflect diversity within synovial tissue (ST). We aimed to identify gene signatures that predict Adalimumab response and provide an initial spatial transcriptomic validation of their cellular context.",

keywords = "Spatial profiling, gene signatures, Rheumatoid Arthritis",

author = "Vincent Wong and Katie Lowe and Annabelle Small and Christopher Altmann and Susanna Proudman and Malcolm Smith and Wittaya Suwakulsiri and Ranjeny Thomas and Kok, \{Chung Hoow\} and Mihir Wechalekar",

year = "2025",

month = oct,

doi = "10.1002/art.43421",

language = "English",

volume = "77",

pages = "963--964",

journal = "Arthritis \& Rheumatology",

issn = "2326-5191",

publisher = "American College of Rheumatology",

number = "S9",

note = "American College of Rheumatology Convergence 2025 ; Conference date: 24-10-2025 Through 29-10-2025",

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Wong, V, Lowe, K, Small, A, Altmann, C, Proudman, S, Smith, M, Suwakulsiri, W, Thomas, R, Kok, CH & Wechalekar, M 2025, 'Spatial profiling of gene signatures in synovial tissue informs treatment strategy for Rheumatoid Arthritis: ACR Convergence 2025 October 24-29, 2025 Chicago, IL', Arthritis & Rheumatology, vol. 77, no. S9, pp. 963-964. https://doi.org/10.1002/art.43421

TY - JOUR

T1 - Spatial profiling of gene signatures in synovial tissue informs treatment strategy for Rheumatoid Arthritis

T2 - American College of Rheumatology Convergence 2025

AU - Wong, Vincent

AU - Lowe, Katie

AU - Small, Annabelle

AU - Altmann, Christopher

AU - Proudman, Susanna

AU - Smith, Malcolm

AU - Suwakulsiri, Wittaya

AU - Thomas, Ranjeny

AU - Kok, Chung Hoow

AU - Wechalekar, Mihir

PY - 2025/10

Y1 - 2025/10

N2 - Background/Purpose: Rheumatoid arthritis (RA) shows heterogeneous therapeutic responses that may reflect diversity within synovial tissue (ST). We aimed to identify gene signatures that predict Adalimumab response and provide an initial spatial transcriptomic validation of their cellular context.

AB - Background/Purpose: Rheumatoid arthritis (RA) shows heterogeneous therapeutic responses that may reflect diversity within synovial tissue (ST). We aimed to identify gene signatures that predict Adalimumab response and provide an initial spatial transcriptomic validation of their cellular context.

KW - Spatial profiling

KW - gene signatures

KW - Rheumatoid Arthritis

UR - https://www.scopus.com/pages/publications/105023911909

U2 - 10.1002/art.43421

DO - 10.1002/art.43421

M3 - Meeting Abstract

SN - 2326-5191

VL - 77

SP - 963

EP - 964

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

IS - S9

Y2 - 24 October 2025 through 29 October 2025

ER -

Spatial profiling of gene signatures in synovial tissue informs treatment strategy for Rheumatoid Arthritis: ACR Convergence 2025 October 24-29, 2025 Chicago, IL

Abstract

Keywords

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