Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining: ACR Convergence 2025 October 24-29, 2025 Chicago, IL

Sonia Presti; Ksenia  Anufrieva; Ce Gao; Sean Prell; Philip Blazar; Jeffrey Lange; Morgan Jones; Mihir Wechalekar; Michael Brenner; Ilya Korsunskly; Shideh Kazerouniian; Kevin Wei

doi:10.1002/art.43421

Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining: ACR Convergence 2025 October 24-29, 2025 Chicago, IL

Sonia Presti
, Ksenia Anufrieva
, Ce Gao
, Sean Prell
, Philip Blazar
, Jeffrey Lange
, Morgan Jones
, Mihir Wechalekar
, Michael Brenner
, Ilya Korsunskly
, Shideh Kazerouniian
, Kevin Wei

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Background/Purpose: The synovial lining is crucial for joint homeostasis, forming a barrier and producing lubricants through specialized fibroblasts. These fibroblasts differ from sublining fibroblasts, which are involved in inflammation and matrix remodeling. While vascular Notch signaling helps define vascular fibroblast positional identity (Wei et al. 2020), the factors shaping synovial lining fibroblast identity are unclear. Using spatial transcriptomics on synovial biopsies from RA patients in remission, we identify a density-dependent mechanism regulating lining fibroblast identity and suggest CREB5, SOX5, and FOXO1 as key transcriptional regulators.

Original language	English
Pages (from-to)	1553-1556
Number of pages	4
Journal	Arthritis & Rheumatology
Volume	77
Issue number	S9
DOIs	https://doi.org/10.1002/art.43421
Publication status	Published - Oct 2025
Externally published	Yes
Event	American College of Rheumatology Convergence 2025 - Chicago, United States Duration: 24 Oct 2025 → 29 Oct 2025

Keywords

synovial lining
joint homeostasis
fibroblasts

Access to Document

10.1002/art.43421Licence: In Copyright

https://acrabstracts.org/abstract/spatial-transcriptomics-identifies-density-sensing-fibroblasts-in-synovial-lining/Licence: In Copyright

Cite this

Presti, S., Anufrieva, K., Gao, C., Prell, S., Blazar, P., Lange, J., Jones, M., Wechalekar, M., Brenner, M., Korsunskly, I., Kazerouniian, S., & Wei, K. (2025). Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining: ACR Convergence 2025 October 24-29, 2025 Chicago, IL. Arthritis & Rheumatology, 77(S9), 1553-1556. https://doi.org/10.1002/art.43421

@article{14ba403c5de6477f8ad8379756bd26b4,

title = "Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining: ACR Convergence 2025 October 24-29, 2025 Chicago, IL",

abstract = "Background/Purpose: The synovial lining is crucial for joint homeostasis, forming a barrier and producing lubricants through specialized fibroblasts. These fibroblasts differ from sublining fibroblasts, which are involved in inflammation and matrix remodeling. While vascular Notch signaling helps define vascular fibroblast positional identity (Wei et al. 2020), the factors shaping synovial lining fibroblast identity are unclear. Using spatial transcriptomics on synovial biopsies from RA patients in remission, we identify a density-dependent mechanism regulating lining fibroblast identity and suggest CREB5, SOX5, and FOXO1 as key transcriptional regulators.",

keywords = "synovial lining, joint homeostasis, fibroblasts",

author = "Sonia Presti and Ksenia Anufrieva and Ce Gao and Sean Prell and Philip Blazar and Jeffrey Lange and Morgan Jones and Mihir Wechalekar and Michael Brenner and Ilya Korsunskly and Shideh Kazerouniian and Kevin Wei",

year = "2025",

month = oct,

doi = "10.1002/art.43421",

language = "English",

volume = "77",

pages = "1553--1556",

journal = "Arthritis \& Rheumatology",

issn = "2326-5191",

publisher = "American College of Rheumatology",

number = "S9",

note = "American College of Rheumatology Convergence 2025 ; Conference date: 24-10-2025 Through 29-10-2025",

}

Presti, S, Anufrieva, K, Gao, C, Prell, S, Blazar, P, Lange, J, Jones, M, Wechalekar, M, Brenner, M, Korsunskly, I, Kazerouniian, S & Wei, K 2025, 'Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining: ACR Convergence 2025 October 24-29, 2025 Chicago, IL', Arthritis & Rheumatology, vol. 77, no. S9, pp. 1553-1556. https://doi.org/10.1002/art.43421

TY - JOUR

T1 - Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining

T2 - American College of Rheumatology Convergence 2025

AU - Presti, Sonia

AU - Anufrieva, Ksenia

AU - Gao, Ce

AU - Prell, Sean

AU - Blazar, Philip

AU - Lange, Jeffrey

AU - Jones, Morgan

AU - Wechalekar, Mihir

AU - Brenner, Michael

AU - Korsunskly, Ilya

AU - Kazerouniian, Shideh

AU - Wei, Kevin

PY - 2025/10

Y1 - 2025/10

N2 - Background/Purpose: The synovial lining is crucial for joint homeostasis, forming a barrier and producing lubricants through specialized fibroblasts. These fibroblasts differ from sublining fibroblasts, which are involved in inflammation and matrix remodeling. While vascular Notch signaling helps define vascular fibroblast positional identity (Wei et al. 2020), the factors shaping synovial lining fibroblast identity are unclear. Using spatial transcriptomics on synovial biopsies from RA patients in remission, we identify a density-dependent mechanism regulating lining fibroblast identity and suggest CREB5, SOX5, and FOXO1 as key transcriptional regulators.

AB - Background/Purpose: The synovial lining is crucial for joint homeostasis, forming a barrier and producing lubricants through specialized fibroblasts. These fibroblasts differ from sublining fibroblasts, which are involved in inflammation and matrix remodeling. While vascular Notch signaling helps define vascular fibroblast positional identity (Wei et al. 2020), the factors shaping synovial lining fibroblast identity are unclear. Using spatial transcriptomics on synovial biopsies from RA patients in remission, we identify a density-dependent mechanism regulating lining fibroblast identity and suggest CREB5, SOX5, and FOXO1 as key transcriptional regulators.

KW - synovial lining

KW - joint homeostasis

KW - fibroblasts

UR - https://www.scopus.com/pages/publications/105023911909

U2 - 10.1002/art.43421

DO - 10.1002/art.43421

M3 - Meeting Abstract

SN - 2326-5191

VL - 77

SP - 1553

EP - 1556

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

IS - S9

Y2 - 24 October 2025 through 29 October 2025

ER -

Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining: ACR Convergence 2025 October 24-29, 2025 Chicago, IL

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this