Specificity of the inhibitory effect of dextropropoxyphene on oxidative drug metabolism in man: effects on theophylline and tolbutamide disposition.

RA Robson, JO Miners, AG Whitehead, DJ Birkett

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Two groups of six healthy male volunteers were studied to assess the possibility of an interaction between dextropropoxyphene and theophylline or tolbutamide using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly or tolbutamide 500 mg i.v. with and without dextropropoxyphene hydrochloride 65 mg 8 hourly. Theophylline 8‐hydroxylation was reduced by a mean of 17% but there were no changes in theophylline 1‐demethylation, theophylline 3‐ demethylation or tolbutamide hydroxylation. 1987 The British Pharmacological Society

Original languageEnglish
Pages (from-to)772-775
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 1987
Externally publishedYes

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