TY - JOUR
T1 - Specificity of the inhibitory effect of dextropropoxyphene on oxidative drug metabolism in man
T2 - effects on theophylline and tolbutamide disposition.
AU - Robson, RA
AU - Miners, JO
AU - Whitehead, AG
AU - Birkett, DJ
PY - 1987/6
Y1 - 1987/6
N2 - Two groups of six healthy male volunteers were studied to assess the possibility of an interaction between dextropropoxyphene and theophylline or tolbutamide using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly or tolbutamide 500 mg i.v. with and without dextropropoxyphene hydrochloride 65 mg 8 hourly. Theophylline 8‐hydroxylation was reduced by a mean of 17% but there were no changes in theophylline 1‐demethylation, theophylline 3‐ demethylation or tolbutamide hydroxylation. 1987 The British Pharmacological Society
AB - Two groups of six healthy male volunteers were studied to assess the possibility of an interaction between dextropropoxyphene and theophylline or tolbutamide using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly or tolbutamide 500 mg i.v. with and without dextropropoxyphene hydrochloride 65 mg 8 hourly. Theophylline 8‐hydroxylation was reduced by a mean of 17% but there were no changes in theophylline 1‐demethylation, theophylline 3‐ demethylation or tolbutamide hydroxylation. 1987 The British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0023251994&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2125.1987.tb03115.x
DO - 10.1111/j.1365-2125.1987.tb03115.x
M3 - Article
C2 - 3606937
AN - SCOPUS:0023251994
SN - 0306-5251
VL - 23
SP - 772
EP - 775
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 6
ER -